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    TAF9B TATA-box binding protein associated factor 9b [ Homo sapiens (human) ]

    Gene ID: 51616, updated on 3-Apr-2024

    Summary

    Official Symbol
    TAF9Bprovided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 9bprovided by HGNC
    Primary source
    HGNC:HGNC:17306
    See related
    Ensembl:ENSG00000187325 MIM:300754; AllianceGenome:HGNC:17306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DN7; DN-7; TAF9L; TAFII31L; TFIID-31
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 16.6), endometrium (RPKM 13.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    Xq21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78129748..78139650, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76564829..76576072, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77385245..77395147, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATPase copper transporting alpha Neighboring gene uncharacterized LOC124905201 Neighboring gene NANOG hESC enhancer GRCh37_chrX:77309981-77310491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29784 Neighboring gene phosphoglycerate kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29785 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:77413269-77414468 Neighboring gene fibronectin type III domain containing 3C, pseudogene Neighboring gene uncharacterized LOC107985669 Neighboring gene MPRA-validated peak7397 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 9B
    Names
    TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
    TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
    TBP-associated factor 9L
    neuronal cell death-related protein 7
    transcription initiation factor IID, 31kD subunit
    transcription-associated factor TAFII31L
    NP_057059.2
    XP_054183157.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012570.1 RefSeqGene

      Range
      5033..14935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015975.5NP_057059.2  transcription initiation factor TFIID subunit 9B

      See identical proteins and their annotated locations for NP_057059.2

      Status: REVIEWED

      Source sequence(s)
      BC010350, BC071649, BI544376
      Consensus CDS
      CCDS35340.1
      UniProtKB/Swiss-Prot
      B2RUZ9, Q9HBM6, Q9Y2S3
      UniProtKB/TrEMBL
      B2R6H6
      Related
      ENSP00000339917.5, ENST00000341864.6
      Conserved Domains (1) summary
      pfam02291
      Location:9130
      TFIID-31kDa; Transcription initiation factor IID, 31kD subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      78129748..78139650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      76564829..76576072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327182.1XP_054183157.1  transcription initiation factor TFIID subunit 9B isoform X1