U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NOP58 NOP58 ribonucleoprotein [ Homo sapiens (human) ]

    Gene ID: 51602, updated on 10-Dec-2024

    Summary

    Official Symbol
    NOP58provided by HGNC
    Official Full Name
    NOP58 ribonucleoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:29926
    See related
    Ensembl:ENSG00000055044 MIM:616742; AllianceGenome:HGNC:29926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOP5; HSPC120; NOP5/NOP58
    Summary
    The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NOP58 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (202265763..202303661)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (202746796..202784682)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (203130486..203168384)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12240 Neighboring gene ribosomal protein L39 pseudogene 14 Neighboring gene short transmembrane mitochondrial protein 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:203114251-203114982 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:203114983-203115714 Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene small nucleolar RNA, C/D box 70B Neighboring gene small nucleolar RNA, C/D box 11B Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene MPRA-validated peak4014 silencer Neighboring gene RNA, 7SL, cytoplasmic 753, pseudogene Neighboring gene PIMREG pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ribonucleoprotein homolog (NOP58), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NOP58 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables TFIID-class transcription factor complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in snoRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of box C/D methylation guide snoRNP complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of pre-snoRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleolar protein 58
    Names
    NOP58 ribonucleoprotein homolog
    nucleolar protein 5
    nucleolar protein NOP5/NOP58

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015934.5NP_057018.1  nucleolar protein 58

      See identical proteins and their annotated locations for NP_057018.1

      Status: REVIEWED

      Source sequence(s)
      BC032592, BP245255
      Consensus CDS
      CCDS2353.1
      UniProtKB/Swiss-Prot
      Q53SA4, Q6PK08, Q9P036, Q9UFN3, Q9Y2X3
      Related
      ENSP00000264279.5, ENST00000264279.10
      Conserved Domains (2) summary
      pfam01798
      Location:168396
      Nop; snoRNA binding domain, fibrillarin
      pfam08156
      Location:266
      NOP5NT; NOP5NT (NUC127) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      202265763..202303661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      202746796..202784682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)