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    CYRIB CYFIP related Rac1 interactor B [ Homo sapiens (human) ]

    Gene ID: 51571, updated on 5-May-2024

    Summary

    Official Symbol
    CYRIBprovided by HGNC
    Official Full Name
    CYFIP related Rac1 interactor Bprovided by HGNC
    Primary source
    HGNC:HGNC:25216
    See related
    Ensembl:ENSG00000153310 MIM:617978; AllianceGenome:HGNC:25216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L1; CYRI; BM-009; CYRI-B; FAM49B
    Summary
    Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bone marrow (RPKM 26.7), appendix (RPKM 26.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CYRIB in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (129839593..130017129, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (130965555..131143607, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (130851839..131029375, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CCDC26 long non-coding RNA Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130526802-130527734 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130527735-130528668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27969 Neighboring gene microRNA 3686 Neighboring gene CRISPRi-validated CCDC26 and MYC e5 enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:130598970-130600169 Neighboring gene MPRA-validated peak7175 silencer Neighboring gene VISTA enhancer hs1709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19540 Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e6 enhancer Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e7 enhancer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:130719165-130720364 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:130722337-130723536 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:130725004-130725177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27970 Neighboring gene mitochondrial translational release factor 1 like pseudogene 2 Neighboring gene gasdermin C Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130844878-130845690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130845691-130846502 Neighboring gene uncharacterized LOC124900265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130881998-130882552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130882553-130883105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899605-130900116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899091-130899604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27972 Neighboring gene MPRA-validated peak7177 silencer Neighboring gene ribosomal protein L15 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130957594-130958094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130971367-130971867 Neighboring gene MPRA-validated peak7178 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27975 Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131005193-131005693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene microRNA 5194 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    EBI GWAS Catalog
    Multiple loci are associated with white blood cell phenotypes.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686B04128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class Ib protein binding, via antigen binding groove ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CYFIP-related Rac1 interactor B
    Names
    FAM49B/JPH1 fusion
    MTSS1/FAM49B fusion
    family with sequence similarity 49 member B
    protein FAM49B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256763.2NP_001243692.1  CYFIP-related Rac1 interactor B isoform 1

      See identical proteins and their annotated locations for NP_001243692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC022973, AK130372, BC003599, BX419336
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429499.1, ENST00000519540.5
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    2. NM_001330612.2NP_001317541.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA975908, AC022973, CN362384, CX165551
      Consensus CDS
      CCDS83327.1
      UniProtKB/Swiss-Prot
      Q9NUQ9
      Related
      ENSP00000429978.1, ENST00000522250.5
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    3. NM_001353242.2NP_001340171.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and includes three alternate exons in the 5' region, compared to variant 1.
      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000384880.2, ENST00000401979.6
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    4. NM_001353243.2NP_001340172.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two exons and includes three alternate exons in the 5' region, compared to variant 1.
      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429802.1, ENST00000523509.5
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    5. NM_001353244.2NP_001340173.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes two alternate internal exons, compared to variant 1.
      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000428117.1, ENST00000522746.5
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    6. NM_001353245.1NP_001340174.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    7. NM_001353246.1NP_001340175.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    8. NM_001353247.1NP_001340176.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    9. NM_001353248.2NP_001340177.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    10. NM_001353249.1NP_001340178.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    11. NM_001353250.1NP_001340179.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429078.1, ENST00000519110.5
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    12. NM_001353251.1NP_001340180.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    13. NM_001353252.1NP_001340181.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    14. NM_001353253.1NP_001340182.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    15. NM_001353254.2NP_001340183.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    16. NM_001353255.1NP_001340184.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    17. NM_001353256.2NP_001340185.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    18. NM_001353257.2NP_001340186.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    19. NM_001353258.2NP_001340187.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000511587.1, ENST00000694912.1
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    20. NM_001353259.2NP_001340188.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    21. NM_001353260.2NP_001340189.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000430674.1, ENST00000517654.5
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    22. NM_001353261.2NP_001340190.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    23. NM_001353262.2NP_001340191.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    24. NM_001353263.2NP_001340192.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    25. NM_001353264.2NP_001340193.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    26. NM_001353265.2NP_001340194.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    27. NM_001353266.2NP_001340195.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    28. NM_001353267.2NP_001340196.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    29. NM_001353268.2NP_001340197.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    30. NM_001353269.1NP_001340198.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    31. NM_001353270.1NP_001340199.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    32. NM_001353271.1NP_001340200.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    33. NM_001353272.1NP_001340201.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    34. NM_001353273.1NP_001340202.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    35. NM_001353274.1NP_001340203.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    36. NM_001353275.1NP_001340204.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    37. NM_001353276.2NP_001340205.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    38. NM_001353277.1NP_001340206.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    39. NM_001353278.1NP_001340207.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    40. NM_001353279.1NP_001340208.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    41. NM_001353280.1NP_001340209.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    42. NM_001353281.1NP_001340210.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    43. NM_001353282.2NP_001340211.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    44. NM_001353283.2NP_001340212.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    45. NM_001353284.2NP_001340213.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    46. NM_001353285.2NP_001340214.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    47. NM_001353286.2NP_001340215.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    48. NM_001353287.2NP_001340216.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    49. NM_001353288.2NP_001340217.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    50. NM_001353289.2NP_001340218.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    51. NM_001353290.2NP_001340219.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    52. NM_001353291.2NP_001340220.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    53. NM_001353292.2NP_001340221.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    54. NM_001353293.2NP_001340222.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    55. NM_001353294.2NP_001340223.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    56. NM_001353295.2NP_001340224.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    57. NM_001353296.2NP_001340225.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    58. NM_001353297.2NP_001340226.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    59. NM_001353298.2NP_001340227.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    60. NM_001353299.2NP_001340228.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    61. NM_001353300.2NP_001340229.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    62. NM_001353301.2NP_001340230.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS83327.1
      Related
      ENSP00000430433.1, ENST00000522941.5
      Conserved Domains (1) summary
      pfam07159
      Location:1174
      DUF1394; Protein of unknown function (DUF1394)
    63. NM_001353302.1NP_001340231.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Related
      ENSP00000515265.1, ENST00000703342.1
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    64. NM_001353303.1NP_001340232.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    65. NM_001353304.1NP_001340233.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    66. NM_001353305.1NP_001340234.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    67. NM_001353306.2NP_001340235.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    68. NM_001353307.2NP_001340236.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    69. NM_001353308.1NP_001340237.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    70. NM_001353309.1NP_001340238.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    71. NM_001353310.2NP_001340239.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    72. NM_001353311.2NP_001340240.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568, KF495742
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    73. NM_001353312.2NP_001340241.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    74. NM_001353313.2NP_001340242.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    75. NM_001353314.2NP_001340243.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    76. NM_001353315.2NP_001340244.1  CYFIP-related Rac1 interactor B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022973
      Consensus CDS
      CCDS94340.1
      UniProtKB/TrEMBL
      A0A8V8TMP7, Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    77. NM_001353316.2NP_001340245.1  CYFIP-related Rac1 interactor B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022973, AC131568
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:17312
      DUF1394; Protein of unknown function (DUF1394)
    78. NM_016623.5NP_057707.3  CYFIP-related Rac1 interactor B isoform 1

      See identical proteins and their annotated locations for NP_057707.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022973, AK130372, BX419336
      Consensus CDS
      CCDS6361.1
      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Related
      ENSP00000429150.1, ENST00000519824.6
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      129839593..130017129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421855.1XP_047277811.1  CYFIP-related Rac1 interactor B isoform X2

    2. XM_011517121.4XP_011515423.2  CYFIP-related Rac1 interactor B isoform X1

    3. XM_047421856.1XP_047277812.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
    4. XM_024447180.2XP_024302948.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
      UniProtKB/TrEMBL
      Q68D08
      Conserved Domains (1) summary
      pfam07159
      Location:18320
      DUF1394; Protein of unknown function (DUF1394)
    5. XM_047421859.1XP_047277815.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
    6. XM_047421857.1XP_047277813.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      130965555..131143607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360636.1XP_054216611.1  CYFIP-related Rac1 interactor B isoform X2

    2. XM_054360635.1XP_054216610.1  CYFIP-related Rac1 interactor B isoform X1

    3. XM_054360638.1XP_054216613.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
    4. XM_054360637.1XP_054216612.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
    5. XM_054360640.1XP_054216615.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7
    6. XM_054360639.1XP_054216614.1  CYFIP-related Rac1 interactor B isoform X3

      UniProtKB/Swiss-Prot
      Q96AZ5, Q9NUQ9, Q9NW21, Q9NZE7