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    ARMCX3 armadillo repeat containing X-linked 3 [ Homo sapiens (human) ]

    Gene ID: 51566, updated on 23-Nov-2021

    Summary

    Official Symbol
    ARMCX3provided by HGNC
    Official Full Name
    armadillo repeat containing X-linked 3provided by HGNC
    Primary source
    HGNC:HGNC:24065
    See related
    Ensembl:ENSG00000102401 MIM:300364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALEX3; GASP6; dJ545K15.2
    Summary
    This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 17.0), thyroid (RPKM 15.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ARMCX3 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101623138..101631910)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100878141..100882833)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 7, pseudogene Neighboring gene armadillo repeat containing X-linked 6 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene armadillo repeat containing X-linked 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0443, MGC12199, DKFZp781N1954

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axonal transport of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    armadillo repeat-containing X-linked protein 3
    Names
    1200004E24Rik
    ARM protein lost in epithelial cancers on chromosome X 3
    arm protein lost in epithelial cancers, X chromosome, 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013222.1 RefSeqGene

      Range
      5022..9714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016607.4NP_057691.1  armadillo repeat-containing X-linked protein 3

      See identical proteins and their annotated locations for NP_057691.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, BC005194, BG035798, BM905704, BX647802
      Consensus CDS
      CCDS14489.1
      UniProtKB/Swiss-Prot
      Q9UH62
      UniProtKB/TrEMBL
      A0A024RCF9
      Related
      ENSP00000340672.4, ENST00000341189.8
      Conserved Domains (2) summary
      sd00043
      Location:156190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112363
      Arm_2; Armadillo-like
    2. NM_177947.3NP_808816.1  armadillo repeat-containing X-linked protein 3

      See identical proteins and their annotated locations for NP_808816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, BC005194, BG035798, BX647802
      Consensus CDS
      CCDS14489.1
      UniProtKB/Swiss-Prot
      Q9UH62
      UniProtKB/TrEMBL
      A0A024RCF9
      Related
      ENSP00000454483.1, ENST00000471229.7
      Conserved Domains (2) summary
      sd00043
      Location:156190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112363
      Arm_2; Armadillo-like
    3. NM_177948.3NP_808817.1  armadillo repeat-containing X-linked protein 3

      See identical proteins and their annotated locations for NP_808817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and represents the shortest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, BC005194, BM905704, BX647802, CA397688
      Consensus CDS
      CCDS14489.1
      UniProtKB/Swiss-Prot
      Q9UH62
      UniProtKB/TrEMBL
      A0A024RCF9
      Related
      ENSP00000439032.1, ENST00000537169.1
      Conserved Domains (2) summary
      sd00043
      Location:156190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112363
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      101623138..101631910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262141.3XP_005262198.1  armadillo repeat-containing X-linked protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005262198.1

      UniProtKB/Swiss-Prot
      Q9UH62
      UniProtKB/TrEMBL
      A0A024RCF9
      Conserved Domains (2) summary
      sd00043
      Location:156190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112363
      Arm_2; Armadillo-like
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