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    RAB14 RAB14, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 51552, updated on 5-Mar-2024

    Summary

    Official Symbol
    RAB14provided by HGNC
    Official Full Name
    RAB14, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:16524
    See related
    Ensembl:ENSG00000119396 MIM:612673; AllianceGenome:HGNC:16524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP; RAB-14
    Summary
    RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
    Expression
    Ubiquitous expression in brain (RPKM 33.7), lung (RPKM 31.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAB14 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121178133..121201869, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133374160..133397896, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123940411..123964147, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene centriolin Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene gelsolin Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB14; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
    Envelope transmembrane glycoprotein gp41 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables myosin V binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi to endosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytic recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in phagolysosome assembly involved in apoptotic cell clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane HDA PubMed 
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear outer membrane-endoplasmic reticulum membrane network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-14
    Names
    F protein-binding protein 1
    bA165P4.3 (member RAS oncogene family)
    small GTP binding protein RAB14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016322.4NP_057406.2  ras-related protein Rab-14

      See identical proteins and their annotated locations for NP_057406.2

      Status: VALIDATED

      Source sequence(s)
      AL137068, AL162081, BC006081, DA404780
      Consensus CDS
      CCDS6827.1
      UniProtKB/Swiss-Prot
      B3KR31, P35287, P61106, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11
      Related
      ENSP00000362946.4, ENST00000373840.9
      Conserved Domains (1) summary
      cd04122
      Location:10175
      Rab14; Rab GTPase family 14 (Rab14)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      121178133..121201869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      133374160..133397896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)