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    ATP5PB ATP synthase peripheral stalk-membrane subunit b [ Homo sapiens (human) ]

    Gene ID: 515, updated on 5-May-2024

    Summary

    Official Symbol
    ATP5PBprovided by HGNC
    Official Full Name
    ATP synthase peripheral stalk-membrane subunit bprovided by HGNC
    Primary source
    HGNC:HGNC:840
    See related
    Ensembl:ENSG00000116459 MIM:603270; AllianceGenome:HGNC:840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG47; ATP5F1
    Summary
    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 107.3), colon (RPKM 76.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ATP5PB in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111449464..111462773)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111464148..111477456)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111992086..112005395)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene UBE2F pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1496 Neighboring gene WD repeat domain 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1497 Neighboring gene chromosome 1 open reading frame 162 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RNA, U6 small nuclear 792, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase, mitochondrial Fo complex, subunit B1 (ATP5F1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 (ATP5F1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC24431

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    ATP synthase F(0) complex subunit B1, mitochondrial
    Names
    ATP synthase B chain, mitochondrial
    ATP synthase proton-transporting mitochondrial F(0) complex subunit B1
    ATP synthase subunit b, mitochondrial
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b
    ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1
    ATPase subunit b
    H+-ATP synthase subunit b
    cell proliferation-inducing protein 47

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001688.5NP_001679.2  ATP synthase F(0) complex subunit B1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001679.2

      Status: REVIEWED

      Source sequence(s)
      AI754631, AL390195, AW778751, BF237506
      Consensus CDS
      CCDS836.1
      UniProtKB/Swiss-Prot
      P24539, Q9BQ68, Q9BRU8
      UniProtKB/TrEMBL
      A0A024R0E1, A8K4W2, Q08ET0, Q53GB3
      Related
      ENSP00000358737.3, ENST00000369722.8
      Conserved Domains (1) summary
      pfam05405
      Location:83244
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      111449464..111462773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      111464148..111477456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002014.1: Suppressed sequence

      Description
      NM_001002014.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    2. NM_001002015.1: Suppressed sequence

      Description
      NM_001002015.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.