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    GULP1 GULP PTB domain containing engulfment adaptor 1 [ Homo sapiens (human) ]

    Gene ID: 51454, updated on 3-Dec-2024

    Summary

    Official Symbol
    GULP1provided by HGNC
    Official Full Name
    GULP PTB domain containing engulfment adaptor 1provided by HGNC
    Primary source
    HGNC:HGNC:18649
    See related
    Ensembl:ENSG00000144366 MIM:608165; AllianceGenome:HGNC:18649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED6; GULP; CED-6
    Summary
    The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in endometrium (RPKM 8.3), prostate (RPKM 7.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GULP1 in Genome Data Viewer
    Location:
    2q32.1-q32.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (188291874..188595926)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (188780647..189084760)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (189156601..189460653)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1090 Neighboring gene MPRA-validated peak3993 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16845 Neighboring gene MPRA-validated peak3994 silencer Neighboring gene arkadia (RNF111) N-terminal like PKA signaling regulator 2N pseudogene Neighboring gene Sharpr-MPRA regulatory region 8723 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189143651-189144345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189158453-189159336 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:189163339-189164538 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189167937-189168854 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:189168855-189169772 Neighboring gene RNA, 5S ribosomal pseudogene 114 Neighboring gene microRNA 561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189260185-189260684 Neighboring gene uncharacterized LOC124906107 Neighboring gene uncharacterized LOC105373790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189538838-189539338 Neighboring gene disrupted in renal carcinoma 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31156

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PTB domain-containing engulfment adapter protein 1
    Names
    GULP, engulfment adaptor PTB domain containing 1
    PTB domain adapter protein CED-6
    PTB domain adaptor protein CED-6
    cell death protein 6 homolog
    engulfment adapter protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252668.2NP_001239597.1  PTB domain-containing engulfment adapter protein 1 isoform b

      See identical proteins and their annotated locations for NP_001239597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS58742.1
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000387144.1, ENST00000409843.5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:136198
      Ax_dynein_light; Axonemal dynein light chain
    2. NM_001252669.2NP_001239598.1  PTB domain-containing engulfment adapter protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS58743.1
      UniProtKB/Swiss-Prot
      Q9UBP9
      Related
      ENSP00000387171.1, ENST00000409805.5
      Conserved Domains (2) summary
      cd14686
      Location:6092
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cl17171
      Location:3154
      PH-like; Pleckstrin homology-like domain
    3. NM_001375925.1NP_001362854.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 5, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000352047.3, ENST00000359135.7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    4. NM_001375926.1NP_001362855.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000386289.1, ENST00000409580.5
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    5. NM_001375927.1NP_001362856.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    6. NM_001375928.1NP_001362857.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    7. NM_001375929.1NP_001362858.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 4-7, 9, and 10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    8. NM_001375930.1NP_001362859.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 4-8, and 10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    9. NM_001375931.1NP_001362860.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1 and 4-9, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    10. NM_001375932.1NP_001362861.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 12-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Related
      ENSP00000514747.1, ENST00000699997.1
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    11. NM_001375933.1NP_001362862.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 11 and 13-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    12. NM_001375934.1NP_001362863.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 11, 12, and 14-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    13. NM_001375935.1NP_001362864.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 11-13 and 15-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    14. NM_001375936.1NP_001362865.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 11-14 and 16-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    15. NM_001375937.1NP_001362866.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 11-15, 17, and 18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    16. NM_001375938.1NP_001362867.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 11-16 and 18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    17. NM_001375939.1NP_001362868.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 11-17, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
    18. NM_001375940.1NP_001362869.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 20-22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    19. NM_001375941.1NP_001362870.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 19, 21, and 22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    20. NM_001375942.1NP_001362871.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 19, 20, and 22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    21. NM_001375943.1NP_001362872.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 19-21, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    22. NM_001375944.1NP_001362873.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 24-26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    23. NM_001375945.1NP_001362874.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 23, 25, and 26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    24. NM_001375946.1NP_001362875.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 23, 24, and 26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    25. NM_001375947.1NP_001362876.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 23-25, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    26. NM_001375948.1NP_001362877.1  PTB domain-containing engulfment adapter protein 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variant 28, encodes the longest isoform (g).
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92916.1
      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Related
      ENSP00000391712.2, ENST00000433052.2
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    27. NM_001375949.1NP_001362878.1  PTB domain-containing engulfment adapter protein 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variant 27, encodes the longest isoform (g).
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92916.1
      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    28. NM_001375950.1NP_001362879.1  PTB domain-containing engulfment adapter protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    29. NM_001375951.1NP_001362880.1  PTB domain-containing engulfment adapter protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (2) summary
      cd01273
      Location:3129
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:108178
      Ax_dynein_light; Axonemal dynein light chain
    30. NM_001375952.1NP_001362881.1  PTB domain-containing engulfment adapter protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (2) summary
      cd14686
      Location:139171
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14133
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    31. NM_001375953.1NP_001362882.1  PTB domain-containing engulfment adapter protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    32. NM_016315.4NP_057399.1  PTB domain-containing engulfment adapter protein 1 isoform a

      See identical proteins and their annotated locations for NP_057399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4, 5, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AF200715, AK055718, AK314498, AL080142
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000386732.1, ENST00000409830.6
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    RNA

    1. NR_164744.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
    2. NR_164745.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      188291874..188595926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712582.2XP_006712645.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712645.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    2. XM_047444715.1XP_047300671.1  PTB domain-containing engulfment adapter protein 1 isoform X13

    3. XM_011511333.2XP_011509635.1  PTB domain-containing engulfment adapter protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011509635.1

      Conserved Domains (2) summary
      cd14686
      Location:117149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    4. XM_047444714.1XP_047300670.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    5. XM_011511329.2XP_011509631.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    6. XM_047444704.1XP_047300660.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    7. XM_047444703.1XP_047300659.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    8. XM_047444697.1XP_047300653.1  PTB domain-containing engulfment adapter protein 1 isoform X6

    9. XM_047444712.1XP_047300668.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    10. XM_047444699.1XP_047300655.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    11. XM_017004307.2XP_016859796.1  PTB domain-containing engulfment adapter protein 1 isoform X10

      Conserved Domains (3) summary
      cd14686
      Location:117149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam04880
      Location:121200
      NUDE_C; NUDE protein, C-terminal conserved region
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    12. XM_006712589.4XP_006712652.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (3) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam04880
      Location:167246
      NUDE_C; NUDE protein, C-terminal conserved region
    13. XM_011511335.3XP_011509637.1  PTB domain-containing engulfment adapter protein 1 isoform X10

      Conserved Domains (3) summary
      cd14686
      Location:117149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam04880
      Location:121200
      NUDE_C; NUDE protein, C-terminal conserved region
      cl17171
      Location:14111
      PH-like; Pleckstrin homology-like domain
    14. XM_006712584.5XP_006712647.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712647.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    15. XM_047444696.1XP_047300652.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    16. XM_047444709.1XP_047300665.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    17. XM_006712583.5XP_006712646.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712646.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    18. XM_047444702.1XP_047300658.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000386867.1, ENST00000409609.5
    19. XM_047444710.1XP_047300666.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    20. XM_006712580.5XP_006712643.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712643.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    21. XM_047444695.1XP_047300651.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    22. XM_047444692.1XP_047300648.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    23. XM_047444707.1XP_047300663.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    24. XM_047444705.1XP_047300661.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    25. XM_047444713.1XP_047300669.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    26. XM_047444701.1XP_047300657.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    27. XM_047444698.1XP_047300654.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    28. XM_047444708.1XP_047300664.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    29. XM_047444706.1XP_047300662.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    30. XM_047444700.1XP_047300656.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    31. XM_047444711.1XP_047300667.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    32. XM_047444691.1XP_047300647.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    33. XM_047444693.1XP_047300649.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    34. XM_011511331.2XP_011509633.1  PTB domain-containing engulfment adapter protein 1 isoform X3

      Conserved Domains (2) summary
      cd14686
      Location:150182
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:5144
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    35. XM_047444694.1XP_047300650.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      188780647..189084760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342469.1XP_054198444.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
    2. XM_054342503.1XP_054198478.1  PTB domain-containing engulfment adapter protein 1 isoform X13

    3. XM_054342478.1XP_054198453.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    4. XM_054342502.1XP_054198477.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    5. XM_054342474.1XP_054198449.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    6. XM_054342491.1XP_054198466.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    7. XM_054342490.1XP_054198465.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    8. XM_054342481.1XP_054198456.1  PTB domain-containing engulfment adapter protein 1 isoform X6

    9. XM_054342501.1XP_054198476.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    10. XM_054342484.1XP_054198459.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    11. XM_054342497.1XP_054198472.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    12. XM_054342482.1XP_054198457.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    13. XM_054342495.1XP_054198470.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    14. XM_054342471.1XP_054198446.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
    15. XM_054342480.1XP_054198455.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    16. XM_054342498.1XP_054198473.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    17. XM_054342472.1XP_054198447.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
    18. XM_054342489.1XP_054198464.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
    19. XM_054342470.1XP_054198445.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
    20. XM_054342488.1XP_054198463.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
    21. XM_054342499.1XP_054198474.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    22. XM_054342468.1XP_054198443.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
    23. XM_054342479.1XP_054198454.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    24. XM_054342475.1XP_054198450.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    25. XM_054342494.1XP_054198469.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    26. XM_054342493.1XP_054198468.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    27. XM_054342487.1XP_054198462.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    28. XM_054342486.1XP_054198461.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    29. XM_054342483.1XP_054198458.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    30. XM_054342496.1XP_054198471.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    31. XM_054342492.1XP_054198467.1  PTB domain-containing engulfment adapter protein 1 isoform X9

      UniProtKB/TrEMBL
      B3KN52
    32. XM_054342485.1XP_054198460.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
    33. XM_054342500.1XP_054198475.1  PTB domain-containing engulfment adapter protein 1 isoform X11

      UniProtKB/TrEMBL
      B3KN52
    34. XM_054342473.1XP_054198448.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    35. XM_054342476.1XP_054198451.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    36. XM_054342477.1XP_054198452.1  PTB domain-containing engulfment adapter protein 1 isoform X4