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    DACT1 dishevelled binding antagonist of beta catenin 1 [ Homo sapiens (human) ]

    Gene ID: 51339, updated on 10-Dec-2024

    Summary

    Official Symbol
    DACT1provided by HGNC
    Official Full Name
    dishevelled binding antagonist of beta catenin 1provided by HGNC
    Primary source
    HGNC:HGNC:17748
    See related
    Ensembl:ENSG00000165617 MIM:607861; AllianceGenome:HGNC:17748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPR1; TBS2; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1
    Summary
    The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in gall bladder (RPKM 10.6), ovary (RPKM 9.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See DACT1 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (58634061..58648321)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (52841138..52855396)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59100779..59115039)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene KIAA0586 Neighboring gene MPRA-validated peak2159 silencer Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:59024296-59024796 Neighboring gene ribosomal protein L9 pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:59092081-59092792 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:59093077-59093701 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:59094888-59095774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:59129886-59130387 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:59130388-59130888 Neighboring gene uncharacterized LOC102723725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:59218720-59219442 Neighboring gene Sharpr-MPRA regulatory region 9975 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:59235232-59235813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:59235814-59236394 Neighboring gene ribosomal protein L31 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables delta-catenin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hindgut morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of beta-catenin-TCF complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Wnt signaling pathway, planar cell polarity pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Wnt signaling pathway, planar cell polarity pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of nodal signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein stability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dapper homolog 1
    Names
    dapper antagonist of catenin 1
    dapper, antagonist of beta-catenin, homolog 1
    hepatocellular carcinoma novel gene 3 protein
    heptacellular carcinoma novel gene 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032025.1 RefSeqGene

      Range
      8895..19254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001079520.2NP_001072988.1  dapper homolog 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at the 3' terminal exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AL133312, BU742074, CN304224, DR001289, DR157190
      Consensus CDS
      CCDS41961.1
      UniProtKB/Swiss-Prot
      Q9NYF0
      Related
      ENSP00000378582.3, ENST00000395153.8
      Conserved Domains (1) summary
      pfam15268
      Location:46799
      Dapper; Dapper
    2. NM_016651.6NP_057735.2  dapper homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_057735.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL133312, BK000256, BU742074, CN304224, DR001289
      Consensus CDS
      CCDS9736.1
      UniProtKB/Swiss-Prot
      A8MYJ2, Q86TY0, Q9NYF0
      Related
      ENSP00000337439.4, ENST00000335867.4
      Conserved Domains (1) summary
      pfam15268
      Location:46836
      Dapper; Dapper

    RNA

    1. NR_046093.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the longest downstream ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF251079, AK316237, AL133312
    2. NR_046095.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF251079, AK299879, AK316164
    3. NR_165650.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL133312
    4. NR_165651.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL133312
    5. NR_165652.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL133312

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      58634061..58648321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      52841138..52855396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)