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    ZDHHC2 zinc finger DHHC-type palmitoyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 51201, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZDHHC2provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:18469
    See related
    Ensembl:ENSG00000104219 MIM:618621; AllianceGenome:HGNC:18469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC2; ZNF372
    Summary
    Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; protein localization to membrane raft; and synapse assembly. Located in Golgi apparatus and endoplasmic reticulum membrane. Is active in postsynaptic recycling endosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZDHHC2 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17156482..17224799)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (17424063..17492390)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17013991..17082308)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27046 Neighboring gene NANOG hESC enhancer GRCh37_chr8:16918455-16918956 Neighboring gene mitochondrial calcium uptake family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18960 Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene NANOG hESC enhancer GRCh37_chr8:17090642-17091144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17104115-17104963 Neighboring gene CCR4-NOT transcription complex subunit 7 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102346 Neighboring gene myotubularin related protein 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of AMPA glutamate receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endosome to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic recycling endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in postsynaptic recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC2
    Names
    DHHC-2
    acyltransferase ZDHHC2
    ream
    rec
    reduced expression associated with metastasis protein
    reduced expression in cancer protein
    testis tissue sperm-binding protein Li 56e
    zinc finger DHHC domain-containing protein 2
    zinc finger DHHC-type containing 2
    zinc finger protein 372
    zinc finger, DHHC domain containing 2
    NP_001349917.1
    NP_001349918.1
    NP_057437.1
    XP_011542846.1
    XP_011542847.1
    XP_011542848.1
    XP_011542850.1
    XP_011542851.1
    XP_024302945.1
    XP_054216590.1
    XP_054216591.1
    XP_054216592.1
    XP_054216593.1
    XP_054216594.1
    XP_054216595.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362988.2NP_001349917.1  palmitoyltransferase ZDHHC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC079193, AC091050
      Conserved Domains (1) summary
      pfam01529
      Location:99220
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_001362989.2NP_001349918.1  palmitoyltransferase ZDHHC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC079193, AC091050
      Conserved Domains (1) summary
      pfam01529
      Location:82203
      DHHC; DHHC palmitoyltransferase
    3. NM_016353.5NP_057437.1  palmitoyltransferase ZDHHC2 isoform 1

      See identical proteins and their annotated locations for NP_057437.1

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC091050
      Consensus CDS
      CCDS47810.1
      UniProtKB/Swiss-Prot
      D3DSP5, Q9UIJ5
      UniProtKB/TrEMBL
      A0A140VKD9
      Related
      ENSP00000262096.8, ENST00000262096.13
      Conserved Domains (1) summary
      cl19890
      Location:13302
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      17156482..17224799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544544.4XP_011542846.1  palmitoyltransferase ZDHHC2 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:172293
      zf-DHHC; DHHC palmitoyltransferase
    2. XM_011544545.4XP_011542847.1  palmitoyltransferase ZDHHC2 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:143264
      zf-DHHC; DHHC palmitoyltransferase
    3. XM_011544549.4XP_011542851.1  palmitoyltransferase ZDHHC2 isoform X6

      Conserved Domains (1) summary
      cl19890
      Location:150203
      zf-DHHC; DHHC palmitoyltransferase
    4. XM_011544546.4XP_011542848.1  palmitoyltransferase ZDHHC2 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:128249
      zf-DHHC; DHHC palmitoyltransferase
    5. XM_024447177.2XP_024302945.1  palmitoyltransferase ZDHHC2 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:82203
      DHHC; DHHC palmitoyltransferase
    6. XM_011544548.4XP_011542850.1  palmitoyltransferase ZDHHC2 isoform X5

      See identical proteins and their annotated locations for XP_011542850.1

      Conserved Domains (1) summary
      pfam01529
      Location:71192
      zf-DHHC; DHHC palmitoyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      17424063..17492390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360615.1XP_054216590.1  palmitoyltransferase ZDHHC2 isoform X1

    2. XM_054360616.1XP_054216591.1  palmitoyltransferase ZDHHC2 isoform X2

    3. XM_054360620.1XP_054216595.1  palmitoyltransferase ZDHHC2 isoform X6

    4. XM_054360617.1XP_054216592.1  palmitoyltransferase ZDHHC2 isoform X3

    5. XM_054360618.1XP_054216593.1  palmitoyltransferase ZDHHC2 isoform X4

    6. XM_054360619.1XP_054216594.1  palmitoyltransferase ZDHHC2 isoform X5