U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HSPA14 heat shock protein family A (Hsp70) member 14 [ Homo sapiens (human) ]

    Gene ID: 51182, updated on 3-Dec-2023

    Summary

    Official Symbol
    HSPA14provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 14provided by HGNC
    Primary source
    HGNC:HGNC:29526
    See related
    Ensembl:ENSG00000187522 MIM:610369; AllianceGenome:HGNC:29526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP70-4; HSP70L1; MSANTD7
    Summary
    Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HSPA14 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14838306..14871741)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14852271..14885706)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14880305..14913740)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14779811-14780332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14793464-14794381 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3085 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr10:14946352-14947052 Neighboring gene SUV39H2 histone lysine methyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3086 Neighboring gene DNA cross-link repair 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:14994732-14995460 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:14995461-14996188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2166 Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of heat shock 70kDa protein 14 (HSPA14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC131990

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    colocalizes_with ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock 70 kDa protein 14
    Names
    HSP70-like protein 1
    heat shock protein HSP60
    heat shock protein hsp70-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016299.4NP_057383.2  heat shock 70 kDa protein 14

      See identical proteins and their annotated locations for NP_057383.2

      Status: VALIDATED

      Source sequence(s)
      AF112210, BC119690, BP201211
      Consensus CDS
      CCDS7103.1
      UniProtKB/Swiss-Prot
      A8K8F8, B0YIY9, Q0VDF9, Q9P0X2, Q9UI07
      Related
      ENSP00000367623.3, ENST00000378372.8
      Conserved Domains (1) summary
      cd10238
      Location:2376
      HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      14838306..14871741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      14852271..14885706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037538.1: Suppressed sequence

      Description
      NM_001037538.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_001278205.1: Suppressed sequence

      Description
      NM_001278205.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    3. NR_103464.2: Suppressed sequence

      Description
      NR_103464.2: This RefSeq was removed because it is thought that this transcript better represents a distinct gene, GeneID: 100421372.