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    HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 [ Homo sapiens (human) ]

    Gene ID: 51170, updated on 5-Mar-2024

    Summary

    Official Symbol
    HSD17B11provided by HGNC
    Official Full Name
    hydroxysteroid 17-beta dehydrogenase 11provided by HGNC
    Primary source
    HGNC:HGNC:22960
    See related
    Ensembl:ENSG00000198189 MIM:612831; AllianceGenome:HGNC:22960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
    Summary
    Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
    Expression
    Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HSD17B11 in Genome Data Viewer
    Location:
    4q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87336515..87391188, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (90665555..90720229, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88257667..88312340, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 5705 Neighboring gene hydroxysteroid 17-beta dehydrogenase 13 Neighboring gene Sharpr-MPRA regulatory region 11108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:88312635-88313207 Neighboring gene RNA, 7SL, cytoplasmic 681, pseudogene Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21707 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88343613-88344547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345091-88345594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345595-88346096 Neighboring gene nudix hydrolase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in androgen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in estrogen biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    estradiol 17-beta-dehydrogenase 11
    Names
    17-beta-hydroxysteroid dehydrogenase type XI
    CTCL tumor antigen HD-CL-03
    CTCL-associated antigen HD-CL-03
    cutaneous T-cell lymphoma-associated antigen HD-CL-03
    dehydrogenase/reductase SDR family member 8
    retinal short-chain dehydrogenase/reductase 2
    short chain dehydrogenase/reductase family 16C member 2
    NP_057329.3
    XP_011530323.1
    XP_054206127.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016245.5NP_057329.3  estradiol 17-beta-dehydrogenase 11 precursor

      See identical proteins and their annotated locations for NP_057329.3

      Status: VALIDATED

      Source sequence(s)
      AC108516, AF273056, BC014327, BM976691, BU838518
      Consensus CDS
      CCDS3619.1
      UniProtKB/Swiss-Prot
      Q8NBQ5, Q96HF6, Q9UKU4
      UniProtKB/TrEMBL
      D6RCD0
      Related
      ENSP00000351035.4, ENST00000358290.9
      Conserved Domains (1) summary
      cd05339
      Location:38277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      87336515..87391188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532021.2XP_011530323.1  estradiol 17-beta-dehydrogenase 11 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:38150
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      90665555..90720229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350152.1XP_054206127.1  estradiol 17-beta-dehydrogenase 11 isoform X1