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    DCTN4 dynactin subunit 4 [ Homo sapiens (human) ]

    Gene ID: 51164, updated on 7-Aug-2022

    Summary

    Official Symbol
    DCTN4provided by HGNC
    Official Full Name
    dynactin subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:15518
    See related
    Ensembl:ENSG00000132912 MIM:614758; AllianceGenome:HGNC:15518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P62; DYN4
    Summary
    Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 24.6), bone marrow (RPKM 19.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DCTN4 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150708440..150759017, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151244948..151295528, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150088002..150138579, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901109 Neighboring gene myozenin 3 Neighboring gene RNA binding motif protein 22 Neighboring gene uncharacterized LOC124901110 Neighboring gene small integral membrane protein 3 Neighboring gene Sharpr-MPRA regulatory region 7532 Neighboring gene immunity related GTPase M

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynactin subunit 4
    Names
    dynactin 4 (p62)
    dynactin p62 subunit
    dynactin subunit p62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135643.2NP_001129115.1  dynactin subunit 4 isoform a

      See identical proteins and their annotated locations for NP_001129115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC008453, AK307757, AL162085, DC321382
      Consensus CDS
      CCDS47310.1
      UniProtKB/Swiss-Prot
      Q9UJW0
      UniProtKB/TrEMBL
      Q9NSJ5
      Related
      ENSP00000414906.2, ENST00000446090.6
      Conserved Domains (1) summary
      pfam05502
      Location:23348
      Dynactin_p62; Dynactin p62 family
    2. NM_001135644.2NP_001129116.1  dynactin subunit 4 isoform c

      See identical proteins and their annotated locations for NP_001129116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks a 7 aa internal segment compared to isoform a.
      Source sequence(s)
      AC008450, AC008453, AK125973, AL162085
      Consensus CDS
      CCDS47311.1
      UniProtKB/Swiss-Prot
      Q9UJW0
      UniProtKB/TrEMBL
      Q9NSJ5
      Related
      ENSP00000411251.1, ENST00000424236.5
      Conserved Domains (1) summary
      pfam05502
      Location:2284
      Dynactin_p62; Dynactin p62 family
    3. NM_016221.4NP_057305.1  dynactin subunit 4 isoform b

      See identical proteins and their annotated locations for NP_057305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC008453, AK000299, AL162085, DC321382
      Consensus CDS
      CCDS4310.1
      UniProtKB/Swiss-Prot
      Q8TAN8, Q9UJW0
      UniProtKB/TrEMBL
      A0A0S2Z5D4, Q9NSJ5
      Related
      ENSP00000416968.2, ENST00000447998.7
      Conserved Domains (1) summary
      pfam05502
      Location:23341
      Dynactin_p62; Dynactin p62 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      150708440..150759017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537644.2XP_011535946.1  dynactin subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_011535946.1

      UniProtKB/Swiss-Prot
      Q9UJW0
      Conserved Domains (1) summary
      pfam05502
      Location:2284
      Dynactin_p62; Dynactin p62 family
    2. XM_047417261.1XP_047273217.1  dynactin subunit 4 isoform X1

    3. XM_011537645.2XP_011535947.1  dynactin subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_011535947.1

      UniProtKB/Swiss-Prot
      Q9UJW0
      Conserved Domains (1) summary
      pfam05502
      Location:2284
      Dynactin_p62; Dynactin p62 family
    4. XM_047417262.1XP_047273218.1  dynactin subunit 4 isoform X2

    5. XM_047417263.1XP_047273219.1  dynactin subunit 4 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      151244948..151295528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)