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    MRPS7 mitochondrial ribosomal protein S7 [ Homo sapiens (human) ]

    Gene ID: 51081, updated on 8-Jul-2021

    Summary

    Official Symbol
    MRPS7provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S7provided by HGNC
    Primary source
    HGNC:HGNC:14499
    See related
    Ensembl:ENSG00000125445 MIM:611974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S7mt; MRP-S; RP-S7; RPMS7; MRP-S7; COXPD34; bMRP27a
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 37.2), kidney (RPKM 29.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MRPS7 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75261879..75266376)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73257960..73262457)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 2 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene MIF4GD divergent transcript Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene growth factor receptor bound protein 2 Neighboring gene ribosomal protein L36a pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    28S ribosomal protein S7, mitochondrial
    Names
    30S ribosomal protein S7 homolog
    bMRP-27a
    mitochondrial small ribosomal subunit protein uS7m
    NP_057055.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015971.4NP_057055.2  28S ribosomal protein S7, mitochondrial

      See identical proteins and their annotated locations for NP_057055.2

      Status: REVIEWED

      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS11718.1
      UniProtKB/Swiss-Prot
      Q9Y2R9
      UniProtKB/TrEMBL
      A0A024R8L0
      Related
      ENSP00000245539.6, ENST00000245539.11
      Conserved Domains (1) summary
      cd14870
      Location:35240
      uS7_Mitochondria_Mammalian; Mammalian Mitochondrial homolog of Ribosomal Protein S7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      75261879..75266376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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