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    MEMO1 mediator of cell motility 1 [ Homo sapiens (human) ]

    Gene ID: 51072, updated on 28-Oct-2024

    Summary

    Official Symbol
    MEMO1provided by HGNC
    Official Full Name
    mediator of cell motility 1provided by HGNC
    Primary source
    HGNC:HGNC:14014
    See related
    Ensembl:ENSG00000162959 MIM:611786; AllianceGenome:HGNC:14014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEMO; C2orf4; CGI-27; NS5ATP7
    Summary
    Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 22.5), bone marrow (RPKM 10.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MEMO1 in Genome Data Viewer
    Location:
    2p22.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (31867823..32011008, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (31916231..32059416, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32092892..32236077, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 52 Neighboring gene adenylate kinase 2 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:32111667-32112574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11332 Neighboring gene MPRA-validated peak3645 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209277-32209778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32209779-32210278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:32225693-32226193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11336 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32236012-32236171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15556 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15557 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32288537-32289337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11339 Neighboring gene spastin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25031, DKFZp434I0135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    protein MEMO1
    Names
    C21orf19-like protein
    HCV NS5A-transactivated protein 7
    hepatitis C virus NS5A-transactivated protein 7
    mediator of ErbB2-driven cell motility 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137602.4NP_001131074.1  protein MEMO1 isoform 2

      See identical proteins and their annotated locations for NP_001131074.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS46255.1
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000400795.2, ENST00000426310.6
      Conserved Domains (1) summary
      cd07361
      Location:9271
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    2. NM_001301833.4NP_001288762.1  protein MEMO1 isoform 1

      See identical proteins and their annotated locations for NP_001288762.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000385557.1, ENST00000404530.6
      Conserved Domains (1) summary
      cd07361
      Location:9294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    3. NM_001301852.4NP_001288781.1  protein MEMO1 isoform 3

      See identical proteins and their annotated locations for NP_001288781.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/Swiss-Prot
      Q9Y316
      Conserved Domains (1) summary
      cl00599
      Location:114198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    4. NM_001371912.2NP_001358841.1  protein MEMO1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:9334
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    5. NM_001371913.2NP_001358842.1  protein MEMO1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:18303
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    6. NM_001371914.2NP_001358843.1  protein MEMO1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000368691.3, ENST00000379383.7
      Conserved Domains (1) summary
      cd07361
      Location:9294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    7. NM_001371916.2NP_001358845.1  protein MEMO1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS46255.1
      UniProtKB/TrEMBL
      A8K3Y8
      Conserved Domains (1) summary
      cd07361
      Location:9271
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    8. NM_001371917.2NP_001358846.1  protein MEMO1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:114198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    9. NM_001371918.2NP_001358847.1  protein MEMO1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:114198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    10. NM_001371920.2NP_001358849.1  protein MEMO1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cd07361
      Location:9196
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    11. NM_001371921.2NP_001358850.1  protein MEMO1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cl00599
      Location:102186
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    12. NM_001385196.1NP_001372125.1  protein MEMO1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Conserved Domains (1) summary
      cd07361
      Location:103388
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
    13. NM_015955.5NP_057039.1  protein MEMO1 isoform 1

      See identical proteins and their annotated locations for NP_057039.1

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Consensus CDS
      CCDS1776.1
      UniProtKB/Swiss-Prot
      B4DLS0, D6W575, Q5R2V8, Q5R2V9, Q6NSL5, Q9Y316
      UniProtKB/TrEMBL
      A8K3Y8
      Related
      ENSP00000295065.4, ENST00000295065.9
      Conserved Domains (1) summary
      cd07361
      Location:9294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    RNA

    1. NR_126032.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
    2. NR_126034.4 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
      Related
      ENST00000490459.5
    3. NR_163995.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
    4. NR_163996.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
    5. NR_163997.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655
    6. NR_163998.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL121652, AL121655

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      31867823..32011008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444636.1XP_047300592.1  protein MEMO1 isoform X2

    2. XM_047444635.1XP_047300591.1  protein MEMO1 isoform X1

    3. XM_011532896.3XP_011531198.1  protein MEMO1 isoform X2

      See identical proteins and their annotated locations for XP_011531198.1

      Conserved Domains (1) summary
      cl00599
      Location:114198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      31916231..32059416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342390.1XP_054198365.1  protein MEMO1 isoform X2

    2. XM_054342389.1XP_054198364.1  protein MEMO1 isoform X1

    3. XM_054342391.1XP_054198366.1  protein MEMO1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001371915.1: Suppressed sequence

      Description
      NM_001371915.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.