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    ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 51046, updated on 10-Dec-2024

    Summary

    Official Symbol
    ST8SIA3provided by HGNC
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:14269
    See related
    Ensembl:ENSG00000177511 MIM:609478; AllianceGenome:HGNC:14269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIAT8C; ST8SiaIII
    Summary
    Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and identical protein binding activity. Involved in several processes, including N-glycan processing; ganglioside biosynthetic process; and sialylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 16.9) and adrenal (RPKM 2.9) See more
    Orthologs
    NEW
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    Genomic context

    See ST8SIA3 in Genome Data Viewer
    Location:
    18q21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (57352557..57368931)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (57553442..57569818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55019788..55036162)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2565 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:54877070-54878269 Neighboring gene RNA, U6 small nuclear 737, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55101332-55101912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55101913-55102492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55104607-55105362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55106119-55106874 Neighboring gene FOXA motif-containing MPRA enhancer 78 Neighboring gene one cut homeobox 2 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_48194 and experimental_48198 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_48219 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_48245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13370 Neighboring gene MPRA-validated peak3163 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr18:55230082-55230255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9481 Neighboring gene ferrochelatase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ganglioside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycoprotein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycosphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oligosaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sialylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3
    Names
    SIAT8-C
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 3
    alpha-2,8-sialyltransferase 8C
    alpha-2,8-sialyltransferase III
    ganglioside GD3 synthase ST8SIA3
    hST8Sia III
    sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase
    sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
    sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)
    sialyltransferase St8Sia III
    sialytransferase St8Sia III
    NP_056963.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015879.3NP_056963.2  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

      See identical proteins and their annotated locations for NP_056963.2

      Status: VALIDATED

      Source sequence(s)
      AB208996, AC090208
      Consensus CDS
      CCDS32834.1
      UniProtKB/Swiss-Prot
      A8K0F2, O43173, Q6B085, Q9NS41
      Related
      ENSP00000320431.2, ENST00000324000.4
      Conserved Domains (1) summary
      pfam00777
      Location:113376
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      57352557..57368931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      57553442..57569818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)