U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SERPINA5 serpin family A member 5 [ Homo sapiens (human) ]

    Gene ID: 5104, updated on 17-Jun-2024

    Summary

    Official Symbol
    SERPINA5provided by HGNC
    Official Full Name
    serpin family A member 5provided by HGNC
    Primary source
    HGNC:HGNC:8723
    See related
    Ensembl:ENSG00000188488 MIM:601841; AllianceGenome:HGNC:8723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
    Summary
    The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
    Expression
    Biased expression in testis (RPKM 322.5), adrenal (RPKM 213.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SERPINA5 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94581426..94593118)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88811397..88823118)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95047763..95059455)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903410 Neighboring gene serpin family A member 4 Neighboring gene uncharacterized LOC112268127 Neighboring gene uncharacterized LOC124903411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95065522-95066360 Neighboring gene serpin family A member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acrosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glycosaminoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet dense tubular network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-KLK3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-PLAT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-PLAU complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-TMPRSS11E complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-TMPRSS7 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-coagulation factor V complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-coagulation factor XI complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-coagulation factor Xa complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-plasma kallikrein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein C inhibitor-thrombin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    plasma serine protease inhibitor
    Names
    acrosomal serine protease inhibitor
    plasminogen activator inhibitor III
    plasminogen activator inhibitor-3
    protein C inhibitor
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032908.2 RefSeqGene

      Range
      24985..36677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_644

    mRNA and Protein(s)

    1. NM_000624.6NP_000615.3  plasma serine protease inhibitor preproprotein

      See identical proteins and their annotated locations for NP_000615.3

      Status: REVIEWED

      Source sequence(s)
      AI114432, AK293192, BC008915, DC394575, HY003178
      Consensus CDS
      CCDS9928.1
      UniProtKB/Swiss-Prot
      P05154, Q07616, Q9UG30
      UniProtKB/TrEMBL
      B3KTV6
      Related
      ENSP00000333203.7, ENST00000329597.12
      Conserved Domains (1) summary
      cd02056
      Location:44403
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      94581426..94593118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88811397..88823118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)