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    UBXN1 UBX domain protein 1 [ Homo sapiens (human) ]

    Gene ID: 51035, updated on 5-May-2024

    Summary

    Official Symbol
    UBXN1provided by HGNC
    Official Full Name
    UBX domain protein 1provided by HGNC
    Primary source
    HGNC:HGNC:18402
    See related
    Ensembl:ENSG00000162191 MIM:616378; AllianceGenome:HGNC:18402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2B28; SAKS1; UBXD10
    Summary
    Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBXN1 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62676500..62679073, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62665920..62668532, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62443972..62446545, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4837 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62437829-62438570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62438571-62439310 Neighboring gene citrate synthase lysine methyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62439311-62440052 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62455030-62455530 Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene LRRN4 C-terminal like Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62465704-62466296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62473607-62474280 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:62475600-62476799 Neighboring gene G protein subunit gamma 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    UBX domain-containing protein 1
    Names
    SAPK substrate protein 1
    UBA/UBX 33.3 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286077.2NP_001273006.1  UBX domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001273006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon structure in the 3' region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC040129
      Consensus CDS
      CCDS66105.1
      UniProtKB/Swiss-Prot
      Q04323, Q9BV93, Q9BVV5
      UniProtKB/TrEMBL
      E9PJ81
      Related
      ENSP00000303991.5, ENST00000301935.10
      Conserved Domains (2) summary
      cd01772
      Location:210293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:545
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    2. NM_001286078.2NP_001273007.1  UBX domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' region and contains an alternate exon structure in the 3' region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC040129, BI855821, BP329601
      Consensus CDS
      CCDS73307.1
      UniProtKB/TrEMBL
      A0A087WTZ5, B4E0P8
      Related
      ENSP00000478250.1, ENST00000616865.4
      Conserved Domains (2) summary
      cd01772
      Location:151234
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:541
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    3. NM_015853.5NP_056937.2  UBX domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056937.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC001372, BP329601
      Consensus CDS
      CCDS8029.1
      UniProtKB/TrEMBL
      E9PJ81
      Related
      ENSP00000294119.2, ENST00000294119.6
      Conserved Domains (2) summary
      cd14302
      Location:545
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
      cl00155
      Location:210283
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62676500..62679073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017874.2XP_016873363.1  UBX domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04323, Q9BV93, Q9BVV5
      UniProtKB/TrEMBL
      E9PJ81
      Related
      ENSP00000435625.1, ENST00000534176.1
      Conserved Domains (2) summary
      cd01772
      Location:210293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:545
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62665920..62668532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369044.1XP_054225019.1  UBX domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04323, Q9BV93, Q9BVV5