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    RRP15 ribosomal RNA processing 15 homolog [ Homo sapiens (human) ]

    Gene ID: 51018, updated on 25-Nov-2025
    Official Symbol
    RRP15provided by HGNC
    Official Full Name
    ribosomal RNA processing 15 homologprovided by HGNC
    Primary source
    HGNC:HGNC:24255
    See related
    Ensembl:ENSG00000067533 MIM:611193; AllianceGenome:HGNC:24255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-115; KIAA0507
    Summary
    This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.4), fat (RPKM 2.2) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
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    Try the new Transcript table
    See RRP15 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (218285293..218337983)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (217520058..217572747)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (218458635..218511325)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 141, pseudogene Neighboring gene uncharacterized LOC105372923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1819 Neighboring gene ribosomal protein S26 pseudogene 17 Neighboring gene TGFB2 antisense RNA 1 Neighboring gene transforming growth factor beta 2

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis. Zhao D, et al. Cancer Lett, 2021 Oct 28. PMID 34343634
    2. RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression. Dong Z, et al. Cell Death Dis, 2023 Feb 7. PMID 36750557, Free PMC Article
    3. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. Dong Z, et al. Oncotarget, 2017 Feb 21. PMID 28099941, Free PMC Article
    4. Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer. Deng Z, et al. Int J Mol Sci, 2023 Feb 9. PMID 36834940, Free PMC Article
    5. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. De Marchis ML, et al. RNA, 2005 Apr. PMID 15769876, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.
      Title: Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.
    2. RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated beta-catenin suppression.
      Title: RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression.
    3. Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis.
      Title: Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis.
    4. Data suggest that ribosomal RNA-processing protein 15 (RRP15) might be a potential target for cancer therapy.
      Title: The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.
    5. The budding yeast homolog of human RRP15 is required for maturation of 60S ribosomal particles
      Title: Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation.
    Submit: New GeneRIF Correction

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0507, MGC22291

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Preferred Names
    RRP15-like protein
    Names
    ribosomal RNA-processing protein 15

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016052.4 → NP_057136.2  RRP15-like protein

      See identical proteins and their annotated locations for NP_057136.2

      Status: REVIEWED

      Source sequence(s)
      AC096638, AW029169, BC020641, BF242786
      Consensus CDS
      CCDS1520.2
      UniProtKB/Swiss-Prot
      Q9Y3B9
      UniProtKB/TrEMBL
      A8K201
      Related
      ENSP00000355899.3, ENST00000366932.4
      Conserved Domains (1) summary
      pfam07890
      Location:102 → 215
      Rrp15p; Rrp15p

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      218285293..218337983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421798.1 → XP_047277754.1  RRP15-like protein isoform X3

      UniProtKB/TrEMBL
      A8K201

    2. XM_047421797.1 → XP_047277753.1  RRP15-like protein isoform X1

    3. XM_011509597.4 → XP_011507899.1  RRP15-like protein isoform X2

      Conserved Domains (1) summary
      pfam07890
      Location:102 → 215
      Rrp15p; Rrp15p

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      217520058..217572747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336842.1 → XP_054192817.1  RRP15-like protein isoform X3

      UniProtKB/TrEMBL
      A8K201

    2. XM_054336840.1 → XP_054192815.1  RRP15-like protein isoform X1

    3. XM_054336841.1 → XP_054192816.1  RRP15-like protein isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y3B9.2 GenPept UniProtKB/Swiss-Prot:Q9Y3B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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