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    Uba2 ubiquitin-like modifier activating enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 50995, updated on 5-Aug-2018

    Summary

    Official Symbol
    Uba2provided by MGI
    Official Full Name
    ubiquitin-like modifier activating enzyme 2provided by MGI
    Primary source
    MGI:MGI:1858313
    See related
    Ensembl:ENSMUSG00000052997 Vega:OTTMUSG00000008405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arx; Sae2; UBA1; Ubl1a2; Uble1b; AA986091
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 54.7), CNS E14 (RPKM 34.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Uba2 in Genome Data Viewer
    Location:
    7; 7 B1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (34140697..34168585, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (34925716..34953548, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene WT1-interacting protein Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene programmed cell death 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO binding ISO
    Inferred from Sequence Orthology
    more info
     
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SUMO-activating enzyme subunit 2
    Names
    SUMO1 activating enzyme subunit 2
    Sumo-1 activating enzyme subunit 2
    anthracycline-associated resistance ARX
    ubiquitin-like 1 (sentrin) activating enzyme E1B
    ubiquitin-like 1 (sentrin) activating enzyme subunit 2
    ubiquitin-like 1-activating enzyme E1B
    NP_057891.1
    XP_017177837.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016682.2NP_057891.1  SUMO-activating enzyme subunit 2

      See identical proteins and their annotated locations for NP_057891.1

      Status: PROVISIONAL

      Source sequence(s)
      BX537302
      Consensus CDS
      CCDS21136.1
      UniProtKB/Swiss-Prot
      Q9Z1F9
      Related
      ENSMUSP00000099807.4, OTTMUSP00000008744, ENSMUST00000102746.10, OTTMUST00000019060
      Conserved Domains (4) summary
      cd01489
      Location:19442
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:9175
      ThiF; ThiF family
      pfam14732
      Location:450536
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:547633
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      34140697..34168585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322348.1XP_017177837.1  SUMO-activating enzyme subunit 2 isoform X1

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