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    Nasp nuclear autoantigenic sperm protein (histone-binding) [ Mus musculus (house mouse) ]

    Gene ID: 50927, updated on 23-Jun-2021

    Summary

    Official Symbol
    Naspprovided by MGI
    Official Full Name
    nuclear autoantigenic sperm protein (histone-binding)provided by MGI
    Primary source
    MGI:MGI:1355328
    See related
    Ensembl:ENSMUSG00000028693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Na; Epcs; Epcs32; Nasp-T; AI131596; AI317140; D4Ertd767; D4Ertd767e; 5033430J04Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 97.7), testis adult (RPKM 45.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nasp in Genome Data Viewer
    Location:
    4 D1; 4 53.24 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116458249..116488894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116601052..116628676, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (116273657..116300556, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene RIKEN cDNA C530005A16 gene Neighboring gene coiled-coil domain containing 17 Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene predicted gene, 25137

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear autoantigenic sperm protein
    Names
    somatic histone binding protein NASP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081475.1NP_001074944.1  nuclear autoantigenic sperm protein isoform 1

      See identical proteins and their annotated locations for NP_001074944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AK083333, AL669953
      Consensus CDS
      CCDS38852.1
      UniProtKB/Swiss-Prot
      Q99MD9
      UniProtKB/TrEMBL
      B1AU76
      Related
      ENSMUSP00000030457.6, ENSMUST00000030457.12
      Conserved Domains (3) summary
      sd00006
      Location:203231
      TPR; TPR repeat [structural motif]
      pfam10516
      Location:203240
      SHNi-TPR; SHNi-TPR
      pfam13424
      Location:200277
      TPR_12; Tetratricopeptide repeat
    2. NM_001284229.1NP_001271158.1  nuclear autoantigenic sperm protein isoform 3

      See identical proteins and their annotated locations for NP_001271158.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AF095722, AK083333, AL669953
      Consensus CDS
      CCDS71451.1
      UniProtKB/Swiss-Prot
      Q99MD9
      Related
      ENSMUSP00000079946.5, ENSMUST00000081182.5
      Conserved Domains (3) summary
      sd00006
      Location:176204
      TPR; TPR repeat [structural motif]
      pfam10516
      Location:176213
      SHNi-TPR; SHNi-TPR
      pfam13424
      Location:173250
      TPR_12; Tetratricopeptide repeat
    3. NM_016777.3NP_058057.3  nuclear autoantigenic sperm protein isoform 2

      See identical proteins and their annotated locations for NP_058057.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AL669953, BX004835
      Consensus CDS
      CCDS18513.1
      UniProtKB/TrEMBL
      B1AU75
      Related
      ENSMUSP00000030456.8, ENSMUST00000030456.14
      Conserved Domains (4) summary
      TIGR00927
      Location:250505
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00006
      Location:528556
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:526602
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:528565
      SHNi-TPR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116458249..116488894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253656.2XP_030109516.1  nuclear autoantigenic sperm protein isoform X1

      Conserved Domains (4) summary
      TIGR00927
      Location:250505
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00006
      Location:528556
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:526602
      TPR_12; Tetratricopeptide repeat
      pfam10516
      Location:528565
      SHNi-TPR
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