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    Exosc10 exosome component 10 [ Mus musculus (house mouse) ]

    Gene ID: 50912, updated on 31-Jan-2019

    Summary

    Official Symbol
    Exosc10provided by MGI
    Official Full Name
    exosome component 10provided by MGI
    Primary source
    MGI:MGI:1355322
    See related
    Ensembl:ENSMUSG00000017264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p2; p3; p4; RRP6; PM-Scl; Pmscl2; PM/Scl-100
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.4), CNS E14 (RPKM 12.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Exosc10 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (148558422..148582401)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (147932536..147956510)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene angiopoietin-like 7 Neighboring gene mannan-binding lectin serine peptidase 2 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CUT catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    dosage compensation by inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear polyadenylation-dependent rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear retention of unspliced pre-mRNA at the site of transcription ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of telomerase RNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptionally active chromatin ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome component 10
    Names
    P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog
    autoantigen PM/Scl 2 homolog
    polymyositis/scleroderma autoantigen 2 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355489.1NP_001342418.1  exosome component 10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA920441, AK081014, AL713995, AW494502, BY294057, CA749889, CF172035, CX205723, DV652107, DV659796
      Conserved Domains (3) summary
      cd06147
      Location:202391
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:420500
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:147
      PMC2NT; PMC2NT (NUC016) domain
    2. NM_001355490.1NP_001342419.1  exosome component 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AK162887, AK168700, AW494502, BY277385
      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46130
      PMC2NT; PMC2NT (NUC016) domain
    3. NM_016699.3NP_057908.2  exosome component 10 isoform 1

      See identical proteins and their annotated locations for NP_057908.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK081014, AK162887, AK168700, AW494502, BY277385
      Consensus CDS
      CCDS18939.1
      UniProtKB/Swiss-Prot
      P56960
      Related
      ENSMUSP00000017408.7, ENSMUST00000017408.13
      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain

    RNA

    1. NR_131061.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK168700, AW494502, BY277385
      Related
      ENSMUST00000097781.10

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      148558422..148582401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539023.3XP_006539086.1  exosome component 10 isoform X1

      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain
    2. XM_017320312.1XP_017175801.1  exosome component 10 isoform X4

    3. XM_006539024.1XP_006539087.1  exosome component 10 isoform X2

      Conserved Domains (3) summary
      cd06147
      Location:202391
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:420500
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:149
      PMC2NT; PMC2NT (NUC016) domain
    4. XM_017320311.1XP_017175800.1  exosome component 10 isoform X3

      Conserved Domains (3) summary
      cd06147
      Location:202391
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:420500
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:147
      PMC2NT; PMC2NT (NUC016) domain
    5. XM_011250300.2XP_011248602.1  exosome component 10 isoform X5

      Conserved Domains (2) summary
      cd06147
      Location:59248
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:277357
      HRDC; Helicase and RNase D C-terminal

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166299.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      1971752..1995618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_131062.2: Suppressed sequence

      Description
      NR_131062.2: This RefSeq was removed because currently there is insufficient support for the transcript.
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