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    Exosc9 exosome component 9 [ Mus musculus (house mouse) ]

    Gene ID: 50911, updated on 26-Feb-2019

    Summary

    Official Symbol
    Exosc9provided by MGI
    Official Full Name
    exosome component 9provided by MGI
    Primary source
    MGI:MGI:1355319
    See related
    Ensembl:ENSMUSG00000027714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p5; p6; RRP45; Pmscl1; PM/Scl-75
    Expression
    Broad expression in liver E14 (RPKM 38.0), liver E14.5 (RPKM 31.2) and 21 other tissues See more
    Orthologs

    Genomic context

    See Exosc9 in Genome Data Viewer
    Location:
    3; 3 B
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (36552606..36565727)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (36451528..36464649)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11549 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 (human) Neighboring gene transient receptor potential cation channel, subfamily C, member 3 Neighboring gene predicted gene, 35856

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AU-rich element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    AU-rich element binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear polyadenylation-dependent mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear polyadenylation-dependent rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear polyadenylation-dependent tRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex component RRP45
    Names
    P75 polymyositis-scleroderma overlap syndrome-associated autoantigen
    autoantigen PM/Scl 1
    exosome complex exonuclease RRP45
    polymyositis/scleroderma autoantigen 1
    polymyositis/scleroderma autoantigen 75 kDa
    NP_062266.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019393.2NP_062266.1  exosome complex component RRP45

      See identical proteins and their annotated locations for NP_062266.1

      Status: VALIDATED

      Source sequence(s)
      AK011636, BE634487, BY078098
      Consensus CDS
      CCDS17312.1
      UniProtKB/Swiss-Prot
      Q9JHI7
      Related
      ENSMUSP00000029269.5, ENSMUST00000029269.11
      Conserved Domains (2) summary
      cd11368
      Location:6264
      RNase_PH_RRP45; RRP45 subunit of eukaryotic exosome
      COG2123
      Location:10271
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      36552606..36565727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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