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    Exosc9 exosome component 9 [ Mus musculus (house mouse) ]

    Gene ID: 50911, updated on 23-Jun-2021

    Summary

    Official Symbol
    Exosc9provided by MGI
    Official Full Name
    exosome component 9provided by MGI
    Primary source
    MGI:MGI:1355319
    See related
    Ensembl:ENSMUSG00000027714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p; RR; p5; p6; Pms; RRP45; PM/Scl; Pmscl1; PM/Scl-75
    Expression
    Broad expression in liver E14 (RPKM 38.0), liver E14.5 (RPKM 31.2) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Exosc9 in Genome Data Viewer
    Location:
    3; 3 B
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36606755..36619876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36552606..36565727)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (36451528..36464649)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 (human) Neighboring gene transient receptor potential cation channel, subfamily C, member 3 Neighboring gene predicted gene, 35856

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic catabolism of deadenylated mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic catabolism of deadenylated mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear polyadenylation-dependent mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex component RRP45
    Names
    P75 polymyositis-scleroderma overlap syndrome-associated autoantigen
    autoantigen PM/Scl 1
    exosome complex exonuclease RRP45
    polymyositis/scleroderma autoantigen 1
    polymyositis/scleroderma autoantigen 75 kDa
    NP_062266.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019393.2NP_062266.1  exosome complex component RRP45

      See identical proteins and their annotated locations for NP_062266.1

      Status: VALIDATED

      Source sequence(s)
      AK011636, BE634487, BY078098
      Consensus CDS
      CCDS17312.1
      UniProtKB/Swiss-Prot
      Q9JHI7
      Related
      ENSMUSP00000029269.6, ENSMUST00000029269.12
      Conserved Domains (2) summary
      cd11368
      Location:6264
      RNase_PH_RRP45; RRP45 subunit of eukaryotic exosome
      COG2123
      Location:10271
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      36606755..36619876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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