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    Nckap1 NCK-associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 50884, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nckap1provided by MGI
    Official Full Name
    NCK-associated protein 1provided by MGI
    Primary source
    MGI:MGI:1355333
    See related
    Ensembl:ENSMUSG00000027002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; H19; Hem2; Nap1; mh19; Hem-2; C79304; p125Nap1; mKIAA0587
    Expression
    Ubiquitous expression in cortex adult (RPKM 59.6), frontal lobe adult (RPKM 57.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Nckap1 in Genome Data Viewer
    Location:
    2 C3; 2 48.21 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (80330856..80411526, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (80500512..80581182, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (80341452..80421122, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene frizzled-related protein Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene N-glycanase 1 pseudogene Neighboring gene predicted gene, 24461 Neighboring gene predicted gene 13688 Neighboring gene dual specificity phosphatase 19 Neighboring gene microRNA 684-1 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apical protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within basal protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within notochord morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within paraxial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within paraxial mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of filamentous actin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nck-associated protein 1
    Names
    brain protein H19
    membrane-associated protein HEM-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290745.1NP_001277674.1  nck-associated protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC060197, BC127067, BP764873, BU055892
      Consensus CDS
      CCDS71082.1
      UniProtKB/TrEMBL
      A1L0U6, A2AS98
      Related
      ENSMUSP00000107390.3, ENSMUST00000111760.3
      Conserved Domains (1) summary
      pfam09735
      Location:131128
      Nckap1; Membrane-associated apoptosis protein
    2. NM_001355410.1NP_001342339.1  nck-associated protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 5' end compared to variant 1, resulting in an isoform (c) that is shorter compared to isoform a.
      Source sequence(s)
      AL928578
      Conserved Domains (1) summary
      pfam09735
      Location:131126
      Nckap1; Membrane-associated apoptosis protein
    3. NM_001355411.1NP_001342340.1  nck-associated protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction in the 5' end compared to variant 1, resulting in an isoform (d) that is shorter compared to isoform a.
      Source sequence(s)
      AL928578
      Conserved Domains (1) summary
      pfam09735
      Location:131120
      Nckap1; Membrane-associated apoptosis protein
    4. NM_016965.3NP_058661.1  nck-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_058661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1, resulting in an isoform (b) that is shorter compared to isoform a.
      Source sequence(s)
      AJ534525, BC060197, BP764873, BU055892
      Consensus CDS
      CCDS16177.1
      UniProtKB/Swiss-Prot
      P28660
      Related
      ENSMUSP00000028386.6, ENSMUST00000028386.12
      Conserved Domains (1) summary
      pfam09735
      Location:131122
      Nckap1; Membrane-associated apoptosis protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      80330856..80411526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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