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    Tmod3 tropomodulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 50875, updated on 8-Aug-2021

    Summary

    Official Symbol
    Tmod3provided by MGI
    Official Full Name
    tropomodulin 3provided by MGI
    Primary source
    MGI:MGI:1355315
    See related
    Ensembl:ENSMUSG00000058587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UTMO; U-Tmo; UTMOD; U-Tmod
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tmod3 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75405066..75466939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75497784..75559657, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (75345591..75407464, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene U6 spliceosomal RNA Neighboring gene predicted gene 7972 Neighboring gene tropomodulin 2 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tropomyosin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tropomodulin-3
    Names
    tropomodulin 3; ubiquitous tropomodulin
    ubiquitous tropomodulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357828.1NP_001344757.1  tropomodulin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC115880, AC123832
      Conserved Domains (1) summary
      cl26161
      Location:60172
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_016963.2NP_058659.1  tropomodulin-3 isoform 1

      See identical proteins and their annotated locations for NP_058659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF237630, AK147017, BY067594
      Consensus CDS
      CCDS23344.1
      UniProtKB/Swiss-Prot
      Q9JHJ0
      UniProtKB/TrEMBL
      Q3TFA9
      Related
      ENSMUSP00000072087.8, ENSMUST00000072232.9
      Conserved Domains (2) summary
      cd00116
      Location:199311
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:5144
      Tropomodulin; Tropomodulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75405066..75466939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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