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    Tmod3 tropomodulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 50875, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tmod3provided by MGI
    Official Full Name
    tropomodulin 3provided by MGI
    Primary source
    MGI:MGI:1355315
    See related
    Ensembl:ENSMUSG00000058587 Vega:OTTMUSG00000062847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UTMOD; U-Tmod
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tmod3 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (75497784..75559687, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (75345591..75407464, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene predicted gene 7972 Neighboring gene tropomodulin 2 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tropomyosin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cellular component movement ISO
    Inferred from Sequence Orthology
    more info
     
    pointed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tropomodulin-3
    Names
    tropomodulin 3; ubiquitous tropomodulin
    ubiquitous tropomodulin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357828.1NP_001344757.1  tropomodulin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC115880, AC123832
      Conserved Domains (1) summary
      cl26161
      Location:60172
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_016963.2NP_058659.1  tropomodulin-3 isoform 1

      See identical proteins and their annotated locations for NP_058659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF237630, AK147017, BY067594
      Consensus CDS
      CCDS23344.1
      UniProtKB/Swiss-Prot
      Q9JHJ0
      UniProtKB/TrEMBL
      Q3TFA9
      Related
      ENSMUSP00000072087.7, OTTMUSP00000079261, ENSMUST00000072232.8, OTTMUST00000153055
      Conserved Domains (2) summary
      cd00116
      Location:199311
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:5144
      Tropomodulin; Tropomodulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      75497784..75559687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313458.1XP_017168947.1  tropomodulin-3 isoform X1

      Conserved Domains (1) summary
      cl26161
      Location:60172
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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