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    HEBP1 heme binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 50865, updated on 27-Nov-2024

    Summary

    Official Symbol
    HEBP1provided by HGNC
    Official Full Name
    heme binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17176
    See related
    Ensembl:ENSG00000013583 MIM:605826; AllianceGenome:HGNC:17176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBP; HEBP
    Summary
    The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 103.7), small intestine (RPKM 72.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HEBP1 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12974870..13000265, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12848536..12873948, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13127804..13153199, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D Neighboring gene small nucleolar RNA SNORD88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13154718-13155263 Neighboring gene 5-hydroxytryptamine receptor 7 pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    heme-binding protein 1
    Names
    p22HBP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015987.5NP_057071.2  heme-binding protein 1

      See identical proteins and their annotated locations for NP_057071.2

      Status: REVIEWED

      Source sequence(s)
      AC007688, AW452041, CF126276
      Consensus CDS
      CCDS31749.1
      UniProtKB/Swiss-Prot
      A8K1G2, Q9NRV9, Q9Y5Z5
      Related
      ENSP00000014930.4, ENST00000014930.9
      Conserved Domains (1) summary
      pfam04832
      Location:13187
      SOUL; SOUL heme-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12974870..13000265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12848536..12873948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)