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    Rnf10 ring finger protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 50849, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rnf10provided by MGI
    Official Full Name
    ring finger protein 10provided by MGI
    Primary source
    MGI:MGI:1859162
    See related
    Ensembl:ENSMUSG00000041740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIE2; AA675014; mKIAA0262
    Summary
    The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 116.7), testis adult (RPKM 98.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rnf10 in Genome Data Viewer
    Location:
    5 F; 5 56.01 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115379829..115410980, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115241770..115272921, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115691779..115722904, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1 Neighboring gene predicted gene, 35515 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) Neighboring gene coenzyme Q5 methyltransferase Neighboring gene dynein light chain LC8-type 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0262

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RING finger protein 10
    Names
    sid 2705

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302448.1NP_001289377.1  RING finger protein 10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA792805, AC145070, AK004579, AK146728
      Consensus CDS
      CCDS80381.1
      UniProtKB/Swiss-Prot
      Q3UIW5
      UniProtKB/TrEMBL
      D3Z1N2
      Related
      ENSMUSP00000107726.2, ENSMUST00000112097.8
      Conserved Domains (1) summary
      pfam13923
      Location:225266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    2. NM_001302449.1NP_001289378.1  RING finger protein 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses alternate in-frame splice sites in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA792805, AC145070, AK034953, AK146728
      Consensus CDS
      CCDS80380.1
      UniProtKB/Swiss-Prot
      Q3UIW5
      UniProtKB/TrEMBL
      H7BX06
      Related
      ENSMUSP00000041778.9, ENSMUST00000040555.15
      Conserved Domains (1) summary
      pfam13923
      Location:225266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    3. NM_016698.2NP_057907.2  RING finger protein 10 isoform 2

      See identical proteins and their annotated locations for NP_057907.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK129106, AK146728, AV451382
      Consensus CDS
      CCDS19584.1
      UniProtKB/Swiss-Prot
      Q3UIW5
      Related
      ENSMUSP00000107725.3, ENSMUST00000112096.9
      Conserved Domains (1) summary
      pfam13923
      Location:225266
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115379829..115410980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320970.2XP_017176459.1  RING finger protein 10 isoform X1

      Conserved Domains (1) summary
      cd16536
      Location:225267
      RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins
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