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    KCNK4 potassium two pore domain channel subfamily K member 4 [ Homo sapiens (human) ]

    Gene ID: 50801, updated on 11-Apr-2024

    Summary

    Official Symbol
    KCNK4provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 4provided by HGNC
    Primary source
    HGNC:HGNC:6279
    See related
    Ensembl:ENSG00000182450 MIM:605720; AllianceGenome:HGNC:6279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FHEIG; TRAAK; K2p4.1; TRAAK1
    Summary
    This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in brain (RPKM 1.0), placenta (RPKM 0.2) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    11q13.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64291302..64300031)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64281266..64289999)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64058774..64067503)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64019089-64019734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64019735-64020381 Neighboring gene phospholipase C beta 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64038093-64038658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64042574-64043234 Neighboring gene G protein-coupled receptor 137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64043895-64044554 Neighboring gene BCL2 associated agonist of cell death Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64046081-64046582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3475 Neighboring gene KCNK4-CATSPERZ readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64066730-64067724 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4897 Neighboring gene estrogen related receptor alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64083535-64084050 Neighboring gene tRNA methyltransferase activator subunit 11-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough KCNK4-CATSPERZ

    Readthrough gene: KCNK4-CATSPERZ, Included gene: CATSPERZ

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mechanosensitive potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables temperature-gated cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to alkaline pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fatty acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to temperature stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of touch ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensory perception of temperature stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium channel subfamily K member 4
    Names
    K2P4.1 potassium channel
    TWIK-related arachidonic acid-stimulated potassium channel protein
    potassium channel, subfamily K, member 4
    potassium channel, two pore domain subfamily K, member 4
    two pore K(+) channel KT4.1
    two pore K+ channel KT4.1
    two pore potassium channel KT4.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317090.2NP_001304019.1  potassium channel subfamily K member 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode the same protein.
      Source sequence(s)
      AP001453, BC110327
      Consensus CDS
      CCDS8067.1
      UniProtKB/Swiss-Prot
      B5TJL1, Q96T94, Q9NYG8
      UniProtKB/TrEMBL
      Q2YDA1
      Related
      ENSP00000378033.2, ENST00000394525.6
      Conserved Domains (1) summary
      pfam07885
      Location:88142
      Ion_trans_2; Ion channel
    2. NM_033310.3NP_201567.1  potassium channel subfamily K member 4

      See identical proteins and their annotated locations for NP_201567.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the functional protein.
      Source sequence(s)
      AF259500, AP001453, BC067791, BC110327, DB273064
      Consensus CDS
      CCDS8067.1
      UniProtKB/Swiss-Prot
      B5TJL1, Q96T94, Q9NYG8
      UniProtKB/TrEMBL
      Q2YDA1
      Related
      ENSP00000402797.2, ENST00000422670.7
      Conserved Domains (1) summary
      pfam07885
      Location:88142
      Ion_trans_2; Ion channel

    RNA

    1. NR_133660.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' most exon, lacks an internal exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AP001453, BC067791
      Related
      ENST00000538767.1
    2. NR_133661.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' most exon and uses an alternate splice site in an internal exon compared to variant 2. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AP001453, BC033577
      Related
      ENST00000541349.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64291302..64300031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64281266..64289999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016611.2: Suppressed sequence

      Description
      NM_016611.2: This RefSeq was permanently suppressed because it is a rare readthrough transcript.