U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Copb2 COPI coat complex subunit beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 50797, updated on 18-Sep-2024

    Summary

    Official Symbol
    Copb2provided by MGI
    Official Full Name
    COPI coat complex subunit beta 2provided by MGI
    Primary source
    MGI:MGI:1354962
    See related
    Ensembl:ENSMUSG00000032458 AllianceGenome:MGI:1354962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein kinase C binding activity. Acts upstream of or within toxin transport. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; liver lobe; nervous system; olfactory epithelium; and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 73.6), CNS E11.5 (RPKM 43.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Copb2 in Genome Data Viewer
    Location:
    9 E3.3; 9 51.4 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98445784..98470428)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98563731..98588375)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene retinol binding protein 2, cellular Neighboring gene RIKEN cDNA 4930579K19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3853 Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene STARR-seq mESC enhancer starr_25005 Neighboring gene RIKEN cDNA E330023G01 gene Neighboring gene predicted gene, 39411

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    coatomer subunit beta'
    Names
    beta'-COP
    beta'-coat protein
    coatomer protein complex, subunit beta 2 (beta prime)
    p102

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015827.2NP_056642.1  coatomer subunit beta'

      See identical proteins and their annotated locations for NP_056642.1

      Status: PROVISIONAL

      Source sequence(s)
      AK088064
      Consensus CDS
      CCDS40734.1
      UniProtKB/Swiss-Prot
      O55029, Q3U5Z9
      Related
      ENSMUSP00000035033.6, ENSMUST00000035033.7
      Conserved Domains (3) summary
      cd00200
      Location:8297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:103140
      7WD40; WD40 repeat [structural motif]
      pfam04053
      Location:319763
      Coatomer_WDAD; Coatomer WD associated region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      98445784..98470428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)