Format

Send to:

Choose Destination
    • Showing Current items.

    Acsl4 acyl-CoA synthetase long-chain family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 50790, updated on 16-Oct-2021

    Summary

    Official Symbol
    Acsl4provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 4provided by MGI
    Primary source
    MGI:MGI:1354713
    See related
    Ensembl:ENSMUSG00000031278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACS4; Facl4; Lacs4; AU018108; 9430020A05Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.0), adrenal adult (RPKM 11.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Acsl4 in Genome Data Viewer
    Location:
    X; X F2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141100989..141173792, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142317993..142390802, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (138752536..138825078, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene x_1100.1 Neighboring gene ribosomal protein L38 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 4
    Names
    LACS 4
    arachidonate--CoA ligase
    fatty acid-Coenzyme A ligase, long chain 4
    long-chain acyl-CoA synthetase 4
    mACS4
    NP_001028772.1
    NP_062350.3
    NP_997508.1
    XP_011246144.1
    XP_011246145.1
    XP_030107239.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033600.1NP_001028772.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

      See identical proteins and their annotated locations for NP_001028772.1

      Status: VALIDATED

      Source sequence(s)
      AL731672, BC016416
      Consensus CDS
      CCDS41156.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Related
      ENSMUSP00000108524.2, ENSMUST00000112903.8
      Conserved Domains (1) summary
      cd17639
      Location:80655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    2. NM_019477.3NP_062350.3  long-chain-fatty-acid--CoA ligase 4 isoform 2

      See identical proteins and their annotated locations for NP_062350.3

      Status: VALIDATED

      Source sequence(s)
      AK054387, AL731672
      Consensus CDS
      CCDS41156.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Related
      ENSMUSP00000108525.2, ENSMUST00000112904.8
      Conserved Domains (1) summary
      cd17639
      Location:80655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    3. NM_207625.2NP_997508.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

      See identical proteins and their annotated locations for NP_997508.1

      Status: VALIDATED

      Source sequence(s)
      AB033886, AL731672, BB857663
      Consensus CDS
      CCDS30448.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      Related
      ENSMUSP00000033634.5, ENSMUST00000033634.5
      Conserved Domains (1) summary
      cd17639
      Location:121696
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      141100989..141173792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251379.2XP_030107239.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

      Conserved Domains (1) summary
      cd17639
      Location:121696
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    2. XM_011247843.4XP_011246145.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

      See identical proteins and their annotated locations for XP_011246145.1

      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Conserved Domains (1) summary
      cd17639
      Location:80655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    3. XM_011247842.4XP_011246144.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

      See identical proteins and their annotated locations for XP_011246144.1

      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Conserved Domains (1) summary
      cd17639
      Location:80655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    Support Center