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    Acsl4 acyl-CoA synthetase long-chain family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 50790, updated on 12-Mar-2019

    Summary

    Official Symbol
    Acsl4provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 4provided by MGI
    Primary source
    MGI:MGI:1354713
    See related
    Ensembl:ENSMUSG00000031278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACS4; Facl4; Lacs4; AU018108; 9430020A05Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.0), adrenal adult (RPKM 11.3) and 23 other tissues See more
    Orthologs

    Genomic context

    See Acsl4 in Genome Data Viewer
    Location:
    X; X F2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (142317993..142390800, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (138752536..138825078, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene x_1100.1 Neighboring gene ribosomal protein L38 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Mitochondria-associated ER Membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 4
    Names
    LACS 4
    fatty acid-Coenzyme A ligase, long chain 4
    long-chain acyl-CoA synthetase 4
    mACS4
    NP_001028772.1
    NP_062350.3
    NP_997508.1
    XP_011246144.1
    XP_011246145.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033600.1NP_001028772.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

      See identical proteins and their annotated locations for NP_001028772.1

      Status: VALIDATED

      Source sequence(s)
      AL731672, BC016416
      Consensus CDS
      CCDS41156.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Related
      ENSMUSP00000108524.1, ENSMUST00000112903.7
      Conserved Domains (1) summary
      cd05927
      Location:80667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_019477.3NP_062350.3  long-chain-fatty-acid--CoA ligase 4 isoform 2

      See identical proteins and their annotated locations for NP_062350.3

      Status: VALIDATED

      Source sequence(s)
      AK054387, AL731672
      Consensus CDS
      CCDS41156.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Related
      ENSMUSP00000108525.1, ENSMUST00000112904.7
      Conserved Domains (1) summary
      cd05927
      Location:80667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. NM_207625.2NP_997508.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

      See identical proteins and their annotated locations for NP_997508.1

      Status: VALIDATED

      Source sequence(s)
      AB033886, AL731672, BB857663
      Consensus CDS
      CCDS30448.1
      UniProtKB/Swiss-Prot
      Q9QUJ7
      Related
      ENSMUSP00000033634.4, ENSMUST00000033634.4
      Conserved Domains (1) summary
      cd05927
      Location:121708
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      142317993..142390800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247843.2XP_011246145.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

      See identical proteins and their annotated locations for XP_011246145.1

      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Conserved Domains (1) summary
      cd05927
      Location:80667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. XM_011247842.2XP_011246144.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

      See identical proteins and their annotated locations for XP_011246144.1

      UniProtKB/Swiss-Prot
      Q9QUJ7
      UniProtKB/TrEMBL
      Q91YN3
      Conserved Domains (1) summary
      cd05927
      Location:80667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
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