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    Fbxl3 F-box and leucine-rich repeat protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 50789, updated on 19-Mar-2019

    Summary

    Official Symbol
    Fbxl3provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 3provided by MGI
    Primary source
    MGI:MGI:1354702
    See related
    Ensembl:ENSMUSG00000022124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBK; Ovtm; Fbl3a; Fbxl3a; Play68; AU041772; AW212966
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 14.1), bladder adult (RPKM 13.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fbxl3 in Genome Data Viewer
    Location:
    14; 14 E2.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (103080239..103099539, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (103479456..103498726, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41236 Neighboring gene ceroid-lipofuscinosis, neuronal 5 Neighboring gene MYC binding protein 2, E3 ubiquitin protein ligase Neighboring gene RIKEN cDNA 1700087I21 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 3
    Names
    F-box and leucine-rich repeat protein 3a
    F-box/LRR-repeat protein 3A
    protein after-hours
    protein overtime

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347600.1NP_001334529.1  F-box/LRR-repeat protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC102815, AK142007, BY146960, BY276318
      Consensus CDS
      CCDS84159.1
      UniProtKB/TrEMBL
      Q5PRF6
    2. NM_001347601.1NP_001334530.1  F-box/LRR-repeat protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC102815, AK142007, BY276318
      Consensus CDS
      CCDS84159.1
      UniProtKB/TrEMBL
      Q5PRF6
    3. NM_001360341.1NP_001347270.1  F-box/LRR-repeat protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102815, AK142007, BC067203
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
    4. NM_001360342.1NP_001347271.1  F-box/LRR-repeat protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102815, AK142007, BC067203, BY146960
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
    5. NM_015822.3NP_056637.1  F-box/LRR-repeat protein 3 isoform 1

      See identical proteins and their annotated locations for NP_056637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK142007, BY787665
      Consensus CDS
      CCDS27315.1
      UniProtKB/Swiss-Prot
      Q8C4V4
      UniProtKB/TrEMBL
      Q5PRF6
      Related
      ENSMUSP00000022720.8, ENSMUST00000022720.14
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      103080239..103099539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519239.3XP_006519302.1  F-box/LRR-repeat protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8C4V4
      UniProtKB/TrEMBL
      Q5PRF6
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
    2. XM_017316078.1XP_017171567.1  F-box/LRR-repeat protein 3 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:279360
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:126151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3669
      F-box-like; F-box-like
    3. XM_006519240.3XP_006519303.1  F-box/LRR-repeat protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006519303.1

      UniProtKB/Swiss-Prot
      Q8C4V4
      Conserved Domains (3) summary
      cd09293
      Location:279360
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:126151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3669
      F-box-like; F-box-like
    4. XM_006519243.3XP_006519306.1  F-box/LRR-repeat protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006519306.1

      UniProtKB/TrEMBL
      Q8BNS3
      Conserved Domains (2) summary
      cd09293
      Location:175256
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:2247
      LRR_AMN1; leucine-rich repeat [structural motif]
    5. XM_006519242.3XP_006519305.1  F-box/LRR-repeat protein 3 isoform X2

      Related
      ENSMUSP00000115843.1, ENSMUST00000132004.7
      Conserved Domains (3) summary
      cd09293
      Location:279360
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:126151
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3669
      F-box-like; F-box-like
    6. XM_006519241.3XP_006519304.1  F-box/LRR-repeat protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8C4V4
      UniProtKB/TrEMBL
      Q5PRF6
      Related
      ENSMUSP00000116044.1, ENSMUST00000145693.7
      Conserved Domains (2) summary
      sd00034
      Location:174199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3677
      F-box-like; F-box-like
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