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    Mapk6 mitogen-activated protein kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 50772, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mapk6provided by MGI
    Official Full Name
    mitogen-activated protein kinase 6provided by MGI
    Primary source
    MGI:MGI:1354946
    See related
    Ensembl:ENSMUSG00000042688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERK; Map; Prk; Erk3; Mapk; Mapk4; Prkm4; Prkm6; Mapk63; 2610021I23Rik; D130053K17Rik
    Expression
    Broad expression in testis adult (RPKM 62.3), CNS E11.5 (RPKM 31.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Mapk6 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75294064..75317303, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75386782..75410016, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (75234708..75257821, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zygote arrest 1-like pseudogene Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in septin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 6
    Names
    Erk-3 related
    MAP kinase 6
    extracellular signal-regulated kinase 3
    mitogen activated protein kinase 4
    protein kinase, mitogen activated kinase 4
    NP_056621.4
    NP_081694.1
    XP_011241069.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015806.5NP_056621.4  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_056621.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, CA325060
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q61532
      Related
      ENSMUSP00000040315.11, ENSMUST00000049355.11
      Conserved Domains (1) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    2. NM_027418.2NP_081694.1  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_081694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, BY737145
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q61532
      Related
      ENSMUSP00000129024.2, ENSMUST00000168937.8
      Conserved Domains (1) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75294064..75317303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242767.4XP_011241069.1  mitogen-activated protein kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_011241069.1

      UniProtKB/Swiss-Prot
      Q61532
      Conserved Domains (1) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
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