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    Mapk6 mitogen-activated protein kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 50772, updated on 12-Aug-2018

    Summary

    Official Symbol
    Mapk6provided by MGI
    Official Full Name
    mitogen-activated protein kinase 6provided by MGI
    Primary source
    MGI:MGI:1354946
    See related
    Ensembl:ENSMUSG00000042688 Vega:OTTMUSG00000037218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erk3; Mapk4; Prkm4; Prkm6; Mapk63; 2610021I23Rik; D130053K17Rik
    Expression
    Broad expression in testis adult (RPKM 62.3), CNS E11.5 (RPKM 31.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See Mapk6 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (75386782..75410019, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (75234708..75257821, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene zygote arrest 1-like pseudogene Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene Leo1, Paf1/RNA polymerase II complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    septin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 6
    Names
    Erk-3 related
    MAP kinase 6
    extracellular signal-regulated kinase 3
    mitogen activated protein kinase 4
    protein kinase, mitogen activated kinase 4
    NP_056621.4
    NP_081694.1
    XP_011241069.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015806.5NP_056621.4  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_056621.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, CA325060
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q61532
      Related
      ENSMUSP00000040315.10, OTTMUSP00000053579, ENSMUST00000049355.10, OTTMUST00000095973
      Conserved Domains (2) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    2. NM_027418.2NP_081694.1  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_081694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, BY737145
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q61532
      Related
      ENSMUSP00000129024.1, ENSMUST00000168937.7
      Conserved Domains (2) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20316
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      75386782..75410019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242767.2XP_011241069.1  mitogen-activated protein kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_011241069.1

      UniProtKB/Swiss-Prot
      Q61532
      Conserved Domains (2) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
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