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    Fbh1 F-box DNA helicase 1 [ Mus musculus (house mouse) ]

    Gene ID: 50755, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbh1provided by MGI
    Official Full Name
    F-box DNA helicase 1provided by MGI
    Primary source
    MGI:MGI:1354699
    See related
    Ensembl:ENSMUSG00000058594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx18; Fbxo1; Fbxo18; AU015756
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.0), limb E14.5 (RPKM 13.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbh1 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11747384..11782396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11742573..11777585, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (11664200..11699154, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39760 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain Neighboring gene predicted gene, 46731 Neighboring gene ankyrin repeat domain 16 Neighboring gene predicted gene, 34768 Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process, endonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork protection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box DNA helicase 1
    Names
    F-box only protein 18
    F-box protein 18
    NP_001335163.1
    NP_001335164.1
    NP_001335165.1
    NP_001335166.1
    NP_056607.1
    XP_006497568.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348234.1NP_001335163.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    2. NM_001348235.1NP_001335164.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    3. NM_001348236.1NP_001335165.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    4. NM_001348237.1NP_001335166.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158937, AL831794, AL845548
      Conserved Domains (2) summary
      COG0210
      Location:365857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136183
      F-box-like; F-box-like
    5. NM_015792.2NP_056607.1  F-box DNA helicase 1 isoform 1

      See identical proteins and their annotated locations for NP_056607.1

      Status: VALIDATED

      Source sequence(s)
      AK003964, AK147829, AL831794, AL845548
      Consensus CDS
      CCDS15688.1
      UniProtKB/Swiss-Prot
      Q8K2I9
      UniProtKB/TrEMBL
      Q3UGP2
      Related
      ENSMUSP00000071495.8, ENSMUST00000071564.14
      Conserved Domains (4) summary
      COG0210
      Location:439931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:210259
      F-box-like; F-box-like
      pfam13538
      Location:870931
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:440684
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11747384..11782396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497505.3XP_006497568.1  F-box DNA helicase 1 isoform X1

      Conserved Domains (3) summary
      COG0210
      Location:439931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:835932
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases
      pfam12937
      Location:210257
      F-box-like
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