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    REG3A regenerating family member 3 alpha [ Homo sapiens (human) ]

    Gene ID: 5068, updated on 17-Jun-2024

    Summary

    Official Symbol
    REG3Aprovided by HGNC
    Official Full Name
    regenerating family member 3 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:8601
    See related
    Ensembl:ENSG00000172016 MIM:167805; AllianceGenome:HGNC:8601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
    Summary
    This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
    Expression
    Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8) See more
    Orthologs
    NEW
    Try the new Gene table
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    Genomic context

    See REG3A in Genome Data Viewer
    Location:
    2p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (79157006..79159753, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (79157332..79160079, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79384132..79386879, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regenerating family member 1 gamma, pseudogene Neighboring gene regenerating family member 1 alpha Neighboring gene uncharacterized LOC105374823 Neighboring gene catenin alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:79620883-79621450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59361 Neighboring gene CTNNA2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ18565

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of detection of glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of keratinocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of keratinocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to symbiotic bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    regenerating islet-derived protein 3-alpha
    Names
    PAP homologous protein
    REG-3-alpha
    hepatocarcinoma-intestine-pancreas
    hepatointestinal pancreatic protein
    human proislet peptide
    pancreatic beta cell growth factor
    pancreatitis-associated protein 1
    proliferation-inducing protein 34
    proliferation-inducing protein 42
    reg III-alpha
    regenerating islet-derived 3 alpha
    regenerating islet-derived protein III-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029902.1 RefSeqGene

      Range
      5002..7749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002580.3NP_002571.1  regenerating islet-derived protein 3-alpha precursor

      See identical proteins and their annotated locations for NP_002571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC036776, BQ777112
      Consensus CDS
      CCDS1965.1
      UniProtKB/Swiss-Prot
      Q06141
      UniProtKB/TrEMBL
      D6W5K0, Q53S56
      Related
      ENSP00000304311.2, ENST00000305165.3
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
    2. NM_138937.3NP_620354.1  regenerating islet-derived protein 3-alpha precursor

      See identical proteins and their annotated locations for NP_620354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK291973, BC036776
      Consensus CDS
      CCDS1965.1
      UniProtKB/Swiss-Prot
      Q06141
      UniProtKB/TrEMBL
      D6W5K0, Q53S56
      Related
      ENSP00000386630.3, ENST00000409839.7
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
    3. NM_138938.3NP_620355.1  regenerating islet-derived protein 3-alpha precursor

      See identical proteins and their annotated locations for NP_620355.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AY544128, BC036776, DC300833
      Consensus CDS
      CCDS1965.1
      UniProtKB/Swiss-Prot
      Q06141
      UniProtKB/TrEMBL
      D6W5K0, Q53S56
      Related
      ENSP00000377456.1, ENST00000393878.5
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      79157006..79159753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      79157332..79160079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)