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    NOX3 NADPH oxidase 3 [ Homo sapiens (human) ]

    Gene ID: 50508, updated on 5-Mar-2024

    Summary

    Official Symbol
    NOX3provided by HGNC
    Official Full Name
    NADPH oxidase 3provided by HGNC
    Primary source
    HGNC:HGNC:7890
    See related
    Ensembl:ENSG00000074771 MIM:607105; AllianceGenome:HGNC:7890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOX-2; GP91-3
    Summary
    This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See NOX3 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (155395368..155455839, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (156597411..156657886, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (155716502..155776973, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155340532-155341032 Neighboring gene TIAM Rac1 associated GEF 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155434365-155434864 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:155440095-155440876 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:155440877-155441659 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:155448114-155449313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155450845-155451460 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17702 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:155499148-155499350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25304 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr6:155506493-155507300 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr6:155507301-155508106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155508589-155509092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155517063-155517562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155539515-155540016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155540017-155540516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155541579-155542078 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:155544888-155546087 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155568469-155569164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155574917-155575491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155575492-155576065 Neighboring gene transcription factor B1, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155635711-155636701 Neighboring gene claudin 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155748671-155749628 Neighboring gene uncharacterized LOC105378068 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:155844790-155845366 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:155964164-155964370 Neighboring gene RNA, U7 small nuclear 152 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
    Nef nef NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells PubMed
    Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed
    tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables superoxide-generating NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables superoxide-generating NADPH oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of gravity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in otolith development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    NADPH oxidase 3
    Names
    NADPH oxidase catalytic subunit-like 3
    gp91phox homolog 3
    mitogenic oxidase 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011995.1 RefSeqGene

      Range
      5065..65536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015718.3NP_056533.1  NADPH oxidase 3

      See identical proteins and their annotated locations for NP_056533.1

      Status: REVIEWED

      Source sequence(s)
      AL031773
      Consensus CDS
      CCDS5250.1
      UniProtKB/Swiss-Prot
      Q9HBJ9, Q9HBY0
      Related
      ENSP00000159060.2, ENST00000159060.3
      Conserved Domains (2) summary
      cd06186
      Location:295568
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:60217
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      155395368..155455839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      156597411..156657886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)