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    Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 [ Mus musculus (house mouse) ]

    Gene ID: 50505, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ercc4provided by MGI
    Official Full Name
    excision repair cross-complementing rodent repair deficiency, complementation group 4provided by MGI
    Primary source
    MGI:MGI:1354163
    See related
    Ensembl:ENSMUSG00000022545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xp; Xpf; AI606920
    Expression
    Ubiquitous expression in testis adult (RPKM 8.4), ovary adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ercc4 in Genome Data Viewer
    Location:
    16; 16 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (12927230..12969873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13109366..13152009)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (13109829..13152102)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930414F18 gene Neighboring gene RIKEN cDNA 1700003L19 gene Neighboring gene ZW10 interactor pseudogene Neighboring gene predicted gene, 32596 Neighboring gene myocardin related transcription factor B Neighboring gene uncharacterized LOC115488652

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 3' overhang single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIID-class transcription factor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within UV protection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protection from non-homologous end joining at telomere ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleotide-excision repair, DNA incision ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair, DNA incision, 3'-to lesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair, DNA incision, 5'-to lesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleotide-excision repair, DNA incision, 5'-to lesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomeric DNA-containing double minutes formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ERCC4-ERCC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleotide-excision repair complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of nucleotide-excision repair factor 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nucleotide-excision repair factor 1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA repair endonuclease XPF
    Names
    DNA excision repair protein ERCC-4
    DNA repair endonuclease subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015769.2NP_056584.2  DNA repair endonuclease XPF

      See identical proteins and their annotated locations for NP_056584.2

      Status: VALIDATED

      Source sequence(s)
      AC166826, AK149326, BQ559127, CD352377, CO433666, CX210668
      Consensus CDS
      CCDS37256.1
      UniProtKB/Swiss-Prot
      Q9QZD4
      UniProtKB/TrEMBL
      Q3UEU6
      Related
      ENSMUSP00000023206.8, ENSMUST00000023206.14
      Conserved Domains (2) summary
      TIGR00596
      Location:97908
      rad1; DNA repair protein (rad1)
      pfam02732
      Location:687817
      ERCC4; ERCC4 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      12927230..12969873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_384576.3 RNA Sequence

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