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    Hspa14 heat shock protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 50497, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hspa14provided by MGI
    Official Full Name
    heat shock protein 14provided by MGI
    Primary source
    MGI:MGI:1354164
    See related
    Ensembl:ENSMUSG00000051396 Ensembl:ENSMUSG00000109865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; NST-1; hsr.1; HSP70L1; Hsp70-4
    Expression
    Ubiquitous expression in placenta adult (RPKM 10.3), liver E14 (RPKM 9.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hspa14 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (3488849..3512936, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (3406126..3430086, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene meiosis expressed gene 1 Neighboring gene DNA cross-link repair 1C Neighboring gene suppressor of variegation 3-9 2 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene LSM7 homolog, U6 small nuclear RNA associated pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock 70 kDa protein 14
    Names
    heat shock 70kDa protein 14
    heat shock protein 4
    heat shock protein, 70 kDa 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355397.1NP_001342326.1  heat shock 70 kDa protein 14 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL732620
      Conserved Domains (1) summary
      cl17037
      Location:27329
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_015765.2NP_056580.2  heat shock 70 kDa protein 14 isoform 1

      See identical proteins and their annotated locations for NP_056580.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer isoform (1).
      Source sequence(s)
      BI734146, BU505607, BY121986, U08215
      Consensus CDS
      CCDS15653.1
      UniProtKB/Swiss-Prot
      Q99M31
      Related
      ENSMUSP00000027961.5, ENSMUST00000027961.11
      Conserved Domains (1) summary
      cd10238
      Location:2376
      HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

    RNA

    1. NR_103465.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains two alternate 3' exons in place of the last several exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK031579, AL732620, BY147434
    2. NR_149715.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate 3' exons in place of the last several exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK150000, AL732620

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      3488849..3512936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238980.2XP_011237282.1  heat shock 70 kDa protein 14 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:27329
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_011238981.1XP_011237283.1  heat shock 70 kDa protein 14 isoform X2

      UniProtKB/TrEMBL
      Q3UDN3
      Related
      ENSMUSP00000120385.2, ENSMUST00000140494.1
      Conserved Domains (1) summary
      pfam13837
      Location:1194
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037542.1: Suppressed sequence

      Description
      NM_001037542.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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