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    Txnrd1 thioredoxin reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 50493, updated on 9-Aug-2021

    Summary

    Official Symbol
    Txnrd1provided by MGI
    Official Full Name
    thioredoxin reductase 1provided by MGI
    Primary source
    MGI:MGI:1354175
    See related
    Ensembl:ENSMUSG00000020250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T; TR; TR1; Trx; TrxR1
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 37.4), large intestine adult (RPKM 32.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Txnrd1 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82669785..82733558)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82833951..82897724)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (82296696..82360469)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene host cell factor C2 Neighboring gene nuclear transcription factor-Y beta Neighboring gene RIKEN cDNA 1700028I16 gene Neighboring gene predicted gene, 38560 Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene predicted gene, 33781 Neighboring gene predicted gene 4799

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables selenate reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thioredoxin-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thioredoxin-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in benzene-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in selenocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thioredoxin reductase 1, cytoplasmic
    Names
    TR alpha
    thioredoxin reductase TR1
    NP_001035978.1
    NP_001035979.1
    NP_001035988.1
    NP_056577.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042513.1NP_001035978.1  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_001035978.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1-3 encode the same isoform.
      Source sequence(s)
      AB027565, AK149625, CJ136679, CJ235434
      Consensus CDS
      CCDS24072.1
      UniProtKB/Swiss-Prot
      Q9JMH6
      Related
      ENSMUSP00000151825.3, ENSMUST00000219962.3
      Conserved Domains (3) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    2. NM_001042514.1NP_001035979.1  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_001035979.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AB027565, CJ235434, CX562215
      Consensus CDS
      CCDS24072.1
      UniProtKB/Swiss-Prot
      Q9JMH6
      Related
      ENSMUSP00000152046.3, ENSMUST00000219442.3
      Conserved Domains (3) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    3. NM_001042523.1NP_001035988.1  thioredoxin reductase 1, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001035988.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the use of an alternate upstream promoter, and contains 2 novel exons compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, resulting from translation initiation at an alternate in-frame start codon, compared to isoform 1.
      Source sequence(s)
      AB027565, AF333036, CJ235434
      Consensus CDS
      CCDS88064.1
      UniProtKB/Swiss-Prot
      Q9JMH6
      Related
      ENSMUSP00000151629.3, ENSMUST00000219368.3
      Conserved Domains (3) summary
      TIGR01438
      Location:125613
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:306382
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:485595
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    4. NM_015762.2NP_056577.2  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_056577.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' non-coding exon; therefore, has a shorter 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AB027565, CJ235434
      Consensus CDS
      CCDS24072.1
      UniProtKB/Swiss-Prot
      Q9JMH6
      Related
      ENSMUSP00000020484.8, ENSMUST00000020484.9
      Conserved Domains (3) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      82669785..82733558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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