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    DEFB107B defensin beta 107B [ Homo sapiens (human) ]

    Gene ID: 503614, updated on 5-Mar-2024

    Summary

    Official Symbol
    DEFB107Bprovided by HGNC
    Official Full Name
    defensin beta 107Bprovided by HGNC
    Primary source
    HGNC:HGNC:31918
    See related
    Ensembl:ENSG00000198129 AllianceGenome:HGNC:31918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT21816
    Summary
    Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See DEFB107B in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7495911..7509311)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7224926..7228864)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7353433..7366833)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene defensin beta 106B Neighboring gene defensin beta 105B Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7355424-7355932 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7355933-7356439 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7363397-7364330 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7364331-7365262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:7375141-7376018 Neighboring gene uncharacterized LOC105377801 Neighboring gene proline-rich protein 23D1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General protein information

    Preferred Names
    beta-defensin 107
    Names
    beta-defensin 7
    defensin, beta 107

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040705.2NP_001035795.1  beta-defensin 107 precursor

      See identical proteins and their annotated locations for NP_001035795.1

      Status: REVIEWED

      Source sequence(s)
      AC134684
      Consensus CDS
      CCDS43696.1
      UniProtKB/Swiss-Prot
      B2RPM1, Q30E75, Q8IZN7, Q8NET2
      Related
      ENSP00000347810.2, ENST00000355602.3
      Conserved Domains (1) summary
      pfam13841
      Location:3564
      Defensin_beta_2; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      7495911..7509311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      5408965..5412906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187570.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      179014..192414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      7224926..7228864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)