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    P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

    Gene ID: 5029, updated on 12-Oct-2019

    Summary

    Official Symbol
    P2RY2provided by HGNC
    Official Full Name
    purinergic receptor P2Y2provided by HGNC
    Primary source
    HGNC:HGNC:8541
    See related
    Ensembl:ENSG00000175591 MIM:600041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
    Summary
    The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
    Orthologs

    Genomic context

    See P2RY2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73200416..73246743)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72928735..72953472)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369381 Neighboring gene Sharpr-MPRA regulatory region 14106 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
    NHGRI GWA Catalog
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
      Nucleotide GPCRs, organism-specific biosystem
      Nucleotide GPCRs
    • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
      Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
    • P2Y receptors, organism-specific biosystem (from REACTOME)
      P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Surfactant metabolism, organism-specific biosystem (from REACTOME)
      Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    cellular ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to ATP TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mucus secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood vessel diameter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 2
    Names
    ATP receptor
    P2U nucleotide receptor
    P2U purinoceptor 1
    P2U receptor 1
    purinergic receptor P2Y, G-protein coupled, 2
    purinoceptor P2Y2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002564.4NP_002555.4  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000377222.2, ENST00000393597.6
    2. NM_176071.3NP_788085.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000377221.2, ENST00000393596.2
    3. NM_176072.3NP_788086.3  P2Y purinoceptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP002761
      Consensus CDS
      CCDS8219.1
      Related
      ENSP00000310305.2, ENST00000311131.6

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      73200416..73246743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017839.1XP_016873328.1  P2Y purinoceptor 2 isoform X1

      UniProtKB/Swiss-Prot
      P41231
      Conserved Domains (1) summary
      pfam00001
      Location:51306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_005274021.4XP_005274078.1  P2Y purinoceptor 2 isoform X1

      See identical proteins and their annotated locations for XP_005274078.1

      UniProtKB/Swiss-Prot
      P41231
      Conserved Domains (1) summary
      pfam00001
      Location:51306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_005274019.4XP_005274076.1  P2Y purinoceptor 2 isoform X1

      See identical proteins and their annotated locations for XP_005274076.1

      UniProtKB/Swiss-Prot
      P41231
      Conserved Domains (1) summary
      pfam00001
      Location:51306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_011545074.2XP_011543376.1  P2Y purinoceptor 2 isoform X1

      See identical proteins and their annotated locations for XP_011543376.1

      UniProtKB/Swiss-Prot
      P41231
      Conserved Domains (1) summary
      pfam00001
      Location:51306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. XM_005274020.4XP_005274077.1  P2Y purinoceptor 2 isoform X1

      See identical proteins and their annotated locations for XP_005274077.1

      UniProtKB/Swiss-Prot
      P41231
      Conserved Domains (1) summary
      pfam00001
      Location:51306
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. XR_001747891.1 RNA Sequence

    2. XR_001747890.1 RNA Sequence

    3. XR_001747892.1 RNA Sequence

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