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    OVGP1 oviductal glycoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 5016, updated on 27-Nov-2024

    Summary

    Official Symbol
    OVGP1provided by HGNC
    Official Full Name
    oviductal glycoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:8524
    See related
    Ensembl:ENSG00000085465 MIM:603578; AllianceGenome:HGNC:8524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGP; OGP; MUC9; CHIT5
    Summary
    This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in endometrium (RPKM 11.4), testis (RPKM 3.0) and 16 other tissues See more
    Orthologs
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    Genomic context

    See OVGP1 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111414319..111427735, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111429011..111442427, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111956941..111970357, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 12 Neighboring gene pepsinogen B, pseudogene Neighboring gene uncharacterized LOC124904309 Neighboring gene NANOG hESC enhancer GRCh37_chr1:111958109-111958610 Neighboring gene UBE2F pseudogene 3 Neighboring gene WD repeat domain 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1495

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: WDR77

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in perivitelline space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    oviduct-specific glycoprotein
    Names
    estrogen-dependent oviduct protein
    mucin 9
    oviduct glycoprotein
    oviductal glycoprotein 1, 120kDa
    oviductin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052675.1 RefSeqGene

      Range
      5043..18459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002557.4NP_002548.3  oviduct-specific glycoprotein precursor

      See identical proteins and their annotated locations for NP_002548.3

      Status: REVIEWED

      Source sequence(s)
      AY189737, U09550
      Consensus CDS
      CCDS834.1
      UniProtKB/Swiss-Prot
      A0AV19, B9EGE1, Q12889, Q15841
      UniProtKB/TrEMBL
      Q86YN0
      Related
      ENSP00000358747.3, ENST00000369732.4
      Conserved Domains (2) summary
      cd02872
      Location:24382
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      COG3889
      Location:368557
      COG3889; Predicted periplasmic protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      111414319..111427735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      111429011..111442427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)