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    ORM1 orosomucoid 1 [ Homo sapiens (human) ]

    Gene ID: 5004, updated on 5-Mar-2024

    Summary

    Official Symbol
    ORM1provided by HGNC
    Official Full Name
    orosomucoid 1provided by HGNC
    Primary source
    HGNC:HGNC:8498
    See related
    Ensembl:ENSG00000229314 MIM:138600; AllianceGenome:HGNC:8498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORM; AGP1; A1AG1; AGP-A; HEL-S-153w
    Summary
    This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 4993.2) See more
    Orthologs
    NEW
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    Genomic context

    See ORM1 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114323098..114326479)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126522292..126525673)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117085378..117088759)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene uncharacterized LOC124902252 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:117050487-117051686 Neighboring gene uncharacterized LOC105376224 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:117068890-117069390 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:117069391-117069891 Neighboring gene Sharpr-MPRA regulatory region 10745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:117096322-117096822 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117129412-117130360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117131354-117132058 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:117143871-117144852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117144987-117145802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117149889-117150624 Neighboring gene uncharacterized LOC124902253

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.
    EBI GWAS Catalog
    Genome-wide association study of Tourette's syndrome.
    EBI GWAS Catalog
    Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM) PubMed
    env Recombinant precursor gp160 (rgp160) or surface unit gp120 (rgp120) of HIV-1 and alpha 1-acid glycoprotein (AGP) show a specific low-affinity binding via N-linked glycans PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-1-acid glycoprotein 1
    Names
    AGP 1
    OMD 1
    epididymis secretory sperm binding protein Li 153w

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012108.1 RefSeqGene

      Range
      5076..8457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000607.4NP_000598.2  alpha-1-acid glycoprotein 1 precursor

      See identical proteins and their annotated locations for NP_000598.2

      Status: REVIEWED

      Source sequence(s)
      AL356796
      Consensus CDS
      CCDS6803.1
      UniProtKB/Swiss-Prot
      B7ZKQ5, P02763, Q5T539, Q5U067, Q8TC16
      UniProtKB/TrEMBL
      V9HWF6
      Related
      ENSP00000259396.8, ENST00000259396.9
      Conserved Domains (1) summary
      pfam00061
      Location:40180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      114323098..114326479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      126522292..126525673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)