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    OPRM1 opioid receptor mu 1 [ Homo sapiens (human) ]

    Gene ID: 4988, updated on 27-May-2024

    Summary

    Official Symbol
    OPRM1provided by HGNC
    Official Full Name
    opioid receptor mu 1provided by HGNC
    Primary source
    HGNC:HGNC:8156
    See related
    Ensembl:ENSG00000112038 MIM:600018; AllianceGenome:HGNC:8156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
    Summary
    This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OPRM1 in Genome Data Viewer
    Location:
    6q25.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (154010496..154246867)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (155212511..155448859)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154331631..154568001)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 896, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:154152732-154153497 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:154165602-154166102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:154182024-154182524 Neighboring gene high mobility group box 3 pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:154360635-154361134 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene MPRA-validated peak6225 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25295 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25296 Neighboring gene MPRA-validated peak6226 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:154663434-154664366 Neighboring gene uncharacterized LOC105378067 Neighboring gene CNKSR family member 3 Neighboring gene Sharpr-MPRA regulatory region 5073 Neighboring gene MPRA-validated peak6228 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cyclic d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), mu-opioid receptor-selective antagonist, significantly delay the febrile response induced by HIV-1 gp120, suggesting that mu-opioid receptors can regulate gp120-induced fever PubMed
    env HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons PubMed
    env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
    env HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression PubMed
    Tat tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
    tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-endorphin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-endorphin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables morphine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables morphine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled opioid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of NMDA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mu-type opioid receptor
    Names
    mu opiate receptor
    mu opioid receptor hMOR-1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021208.2 RefSeqGene

      Range
      33740..241367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1007

    mRNA and Protein(s)

    1. NM_000914.5NP_000905.3  mu-type opioid receptor isoform MOR-1

      See identical proteins and their annotated locations for NP_000905.3

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS55070.1
      UniProtKB/Swiss-Prot
      B0FXJ1, B2R9S7, B8Q1L7, B8Q1L8, B8Q1L9, E7EWZ3, G8XRH6, G8XRH8, P35372, Q12930, Q4VWM1, Q4VWM2, Q4VWM3, Q4VWM4, Q4VWM6, Q4VWX6, Q5TDA1, Q6UPP1, Q6UQ80, Q7Z2D8, Q86V80, Q8IWW3, Q8IWW4, Q9UCZ4, Q9UN57
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000328264.7, ENST00000330432.12
      Conserved Domains (1) summary
      cd15090
      Location:71349
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001008503.3NP_001008503.2  mu-type opioid receptor isoform MOR-1O

      See identical proteins and their annotated locations for NP_001008503.2

      Status: REVIEWED

      Source sequence(s)
      AL136444, AL445220
      Consensus CDS
      CCDS43517.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000338381.4, ENST00000337049.8
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    3. NM_001008504.4NP_001008504.2  mu-type opioid receptor isoform MOR-1A

      See identical proteins and their annotated locations for NP_001008504.2

      Status: REVIEWED

      Source sequence(s)
      AL136444
      Consensus CDS
      CCDS47508.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000411903.2, ENST00000428397.6
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    4. NM_001008505.2NP_001008505.2  mu-type opioid receptor isoform MOR-1X

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL136444, AY036622, FJ041291
      Consensus CDS
      CCDS43518.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000229768.5, ENST00000229768.9
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    5. NM_001145279.4NP_001138751.1  mu-type opioid receptor isoform MOR-1i

      See identical proteins and their annotated locations for NP_001138751.1

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS47503.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000394624.2, ENST00000434900.6
      Conserved Domains (1) summary
      cd15090
      Location:164442
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_001145280.4NP_001138752.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001138752.1

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS55071.1
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENSP00000430876.1, ENST00000520708.5
      Conserved Domains (1) summary
      cd15090
      Location:1249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_001145281.3NP_001138753.1  mu-type opioid receptor isoform MOR-1G2

      See identical proteins and their annotated locations for NP_001138753.1

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS55068.1
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENSP00000430260.1, ENST00000518759.5
      Conserved Domains (1) summary
      cd15090
      Location:16268
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001145282.2NP_001138754.1  mu-type opioid receptor isoform MOR-1B1

      See identical proteins and their annotated locations for NP_001138754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL136444, AY225404, FJ041291
      Consensus CDS
      CCDS47504.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000410497.2, ENST00000452687.6
      Conserved Domains (1) summary
      cd15090
      Location:71349
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001145283.2NP_001138755.1  mu-type opioid receptor isoform MOR-1B2

      See identical proteins and their annotated locations for NP_001138755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, AY309005, FJ041291
      Consensus CDS
      CCDS47505.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000413752.2, ENST00000435918.6
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    10. NM_001145284.3NP_001138756.1  mu-type opioid receptor isoform MOR-1B3

      See identical proteins and their annotated locations for NP_001138756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, AY309006, FJ041291
      Consensus CDS
      CCDS47506.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000399359.2, ENST00000414028.6
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    11. NM_001145285.3NP_001138757.1  mu-type opioid receptor isoform MOR-1B4

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS55069.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000430097.1, ENST00000524163.5
      Conserved Domains (1) summary
      cd15090
      Location:71349
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    12. NM_001145286.3NP_001138758.1  mu-type opioid receptor isoform MOR-1B5

      Status: REVIEWED

      Source sequence(s)
      AL132774, AL136444
      Consensus CDS
      CCDS47507.1
      UniProtKB/TrEMBL
      G8XRH5
      Related
      ENSP00000403549.2, ENST00000419506.6
      Conserved Domains (1) summary
      cd15090
      Location:71349
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    13. NM_001145287.3NP_001138759.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001138759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
      Source sequence(s)
      AL132774, AL136444, EU362990
      Consensus CDS
      CCDS55071.1
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENSP00000429373.1, ENST00000522236.1
      Conserved Domains (1) summary
      cd15090
      Location:1249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    14. NM_001285522.1NP_001272451.1  mu-type opioid receptor isoform MOR-1S

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1S) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks two alternate internal exons, compared to variant MOR-1i. The resulting isoform (MOR-1S) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
      Source sequence(s)
      AL132774, FJ041290, FJ041291
      UniProtKB/TrEMBL
      C9E9Z9
      Conserved Domains (2) summary
      cd14964
      Location:7396
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:7196
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    15. NM_001285523.3NP_001272452.1  mu-type opioid receptor isoform MOR-1A2

      See identical proteins and their annotated locations for NP_001272452.1

      Status: REVIEWED

      Source sequence(s)
      AL136444
      UniProtKB/TrEMBL
      L0E130
      Related
      ENSP00000353598.5, ENST00000360422.8
      Conserved Domains (2) summary
      pfam00001
      Location:87338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    16. NM_001285524.1NP_001272453.1  mu-type opioid receptor isoform MOR-1i

      See identical proteins and their annotated locations for NP_001272453.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1CA) represents use of an alternate promoter and 5' UTR, compared to variant MOR-1i. Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
      Source sequence(s)
      AL132774, FJ041292
      Consensus CDS
      CCDS47503.1
      UniProtKB/TrEMBL
      G8XRH5
      Conserved Domains (1) summary
      cd15090
      Location:164442
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    17. NM_001285526.2NP_001272455.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001272455.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1K2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
      Source sequence(s)
      AL132774, AL136444, EU360599
      Consensus CDS
      CCDS55071.1
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENSP00000429719.1, ENST00000522555.5
      Conserved Domains (1) summary
      cd15090
      Location:1249
      7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
    18. NM_001285527.1NP_001272456.1  mu-type opioid receptor isoform MOR-1W

      See identical proteins and their annotated locations for NP_001272456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1W; also known as mu3-like and MOR-1A delta) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1W) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AY364890
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENST00000522382.1
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    19. NM_001285528.2NP_001272457.1  mu-type opioid receptor isoform MOR-3

      See identical proteins and their annotated locations for NP_001272457.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-3; also known as mu3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AY195733, AY364890
      UniProtKB/TrEMBL
      C7E9I8
      Related
      ENST00000521106.1
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor

    RNA

    1. NR_104348.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y3; also known as MOR-1V) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, FJ041291, FJ041293, FJ041294
    2. NR_104349.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y2) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY225404, FJ041291, FJ041294
    3. NR_104350.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Z) represents use of an alternate promoter and lacks an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, FJ041291, HQ699462
    4. NR_104351.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, AY309009, FJ041291
      Related
      ENST00000519083.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      154010496..154246867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418837.1XP_047274793.1  mu-type opioid receptor isoform X2

      UniProtKB/TrEMBL
      A0A6H0WF09
      Conserved Domains (2) summary
      cd14964
      Location:135159
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:133159
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017010907.3XP_016866396.1  mu-type opioid receptor isoform X3

      UniProtKB/TrEMBL
      G8XRH4
      Conserved Domains (2) summary
      cd14964
      Location:135159
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:133180
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_011535862.3XP_011534164.1  mu-type opioid receptor isoform X1

      See identical proteins and their annotated locations for XP_011534164.1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    4. XM_011535856.3XP_011534158.1  mu-type opioid receptor isoform X1

      See identical proteins and their annotated locations for XP_011534158.1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    5. XM_011535853.3XP_011534155.1  mu-type opioid receptor isoform X1

      See identical proteins and their annotated locations for XP_011534155.1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    6. XM_017010903.3XP_016866392.1  mu-type opioid receptor isoform X1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    7. XM_011535851.4XP_011534153.1  mu-type opioid receptor isoform X1

      See identical proteins and their annotated locations for XP_011534153.1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    8. XM_017010904.2XP_016866393.1  mu-type opioid receptor isoform X1

      UniProtKB/TrEMBL
      C7E9I8
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      155212511..155448859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)