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    OPRL1 opioid related nociceptin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4987, updated on 19-Sep-2024

    Summary

    Official Symbol
    OPRL1provided by HGNC
    Official Full Name
    opioid related nociceptin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:8155
    See related
    Ensembl:ENSG00000125510 MIM:602548; AllianceGenome:HGNC:8155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR
    Summary
    The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See OPRL1 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64080082..64100643)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65900137..65922785)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62711435..62731996)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene transcription elongation factor A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene MPRA-validated peak4324 silencer Neighboring gene LKAAEAR motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723260-62723993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723994-62724726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62732783-62733284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62740950-62741133 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62751601-62752100 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62754467-62755666 Neighboring gene B6.7 minisatellite repeat instability region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62768655-62769156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62769157-62769656 Neighboring gene uncharacterized LOC105372727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62771493-62772406

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34578

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nociceptin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nociceptin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in conditioned place preference IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of locomotor rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nociceptin receptor
    Names
    kappa-type 3 opioid receptor
    kappa3-related opioid receptor
    nociceptin/orphanin FQ receptor
    opiate receptor-like 1
    orphanin FQ receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000913.6NP_000904.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_000904.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' non-coding region; therefore, has a shorter 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
      Related
      ENSP00000347848.4, ENST00000355631.8
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001200019.2NP_001186948.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_001186948.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' non-coding exons; therefore, has a different 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL590548, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
      Related
      ENSP00000336764.3, ENST00000349451.3
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001318853.2NP_001305782.1  nociceptin receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      Consensus CDS
      CCDS93075.1
      UniProtKB/TrEMBL
      A0A5F9ZI64, Q6FGM5
      Related
      ENSP00000500894.2, ENST00000672146.3
      Conserved Domains (2) summary
      pfam00001
      Location:68319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66188
      7tm_4; Olfactory receptor
    4. NM_001318854.1NP_001305783.1  nociceptin receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate, in-frame acceptor splice site in the 5' coding region compared to variant 1. The resulting isoform (2, also known as KOR-3D) is shorter, missing a 5 aa protein segment compared to isoform 1.
      Source sequence(s)
      AF126470, AL121581, BC038433, CB048300, R17579
      UniProtKB/TrEMBL
      Q6FGM5
      Conserved Domains (2) summary
      pfam00001
      Location:68314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66183
      7tm_4; Olfactory receptor
    5. NM_001318855.1NP_001305784.1  nociceptin receptor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate acceptor splice site in the 5' coding region, which results in translation initiation from an alternate, downstream start codon compared to variant 1. The encoded isoform (3, also known as KOR-3A) is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF115266, AL121581, BC038433, CB048300, R17579
      UniProtKB/TrEMBL
      A0A0G2JQE4, Q8IXB0
      Conserved Domains (2) summary
      pfam00001
      Location:48290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:112159
      7tm_4; Olfactory receptor
    6. NM_182647.4NP_872588.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_872588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
      Related
      ENSP00000336843.2, ENST00000336866.7
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      64080082..64100643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440155.1XP_047296111.1  nociceptin receptor isoform X3

      UniProtKB/TrEMBL
      Q6FGM5
    2. XM_047440156.1XP_047296112.1  nociceptin receptor isoform X3

      UniProtKB/TrEMBL
      Q6FGM5
    3. XM_047440157.1XP_047296113.1  nociceptin receptor isoform X4

      UniProtKB/TrEMBL
      A0A0G2JQE4
    4. XM_047440154.1XP_047296110.1  nociceptin receptor isoform X2

      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
    5. XM_011528828.4XP_011527130.1  nociceptin receptor isoform X1

      UniProtKB/TrEMBL
      Q6FGM5
      Conserved Domains (2) summary
      pfam00001
      Location:86337
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:84206
      7tm_4; Olfactory receptor
    6. XM_011528830.4XP_011527132.1  nociceptin receptor isoform X4

      See identical proteins and their annotated locations for XP_011527132.1

      UniProtKB/TrEMBL
      A0A0G2JQE4
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60107
      7tm_4; Olfactory receptor
    7. XM_047440153.1XP_047296109.1  nociceptin receptor isoform X1

      UniProtKB/TrEMBL
      Q6FGM5

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187624.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2723..5589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65900137..65922785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323463.1XP_054179438.1  nociceptin receptor isoform X3

      UniProtKB/TrEMBL
      Q6FGM5
    2. XM_054323464.1XP_054179439.1  nociceptin receptor isoform X3

      UniProtKB/TrEMBL
      Q6FGM5
    3. XM_054323465.1XP_054179440.1  nociceptin receptor isoform X4

      UniProtKB/TrEMBL
      A0A0G2JQE4
    4. XM_054323461.1XP_054179436.1  nociceptin receptor isoform X2

      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
    5. XM_054323462.1XP_054179437.1  nociceptin receptor isoform X2

      UniProtKB/Swiss-Prot
      P41146, Q8TD34, Q8WYH9, Q9H4K4
      UniProtKB/TrEMBL
      Q6FGM5
    6. XM_054323459.1XP_054179434.1  nociceptin receptor isoform X1

      UniProtKB/TrEMBL
      Q6FGM5
    7. XM_054323466.1XP_054179441.1  nociceptin receptor isoform X4

      UniProtKB/TrEMBL
      A0A0G2JQE4
    8. XM_054323460.1XP_054179435.1  nociceptin receptor isoform X1

      UniProtKB/TrEMBL
      Q6FGM5