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    OPRK1 opioid receptor kappa 1 [ Homo sapiens (human) ]

    Gene ID: 4986, updated on 11-Apr-2024

    Summary

    Official Symbol
    OPRK1provided by HGNC
    Official Full Name
    opioid receptor kappa 1provided by HGNC
    Primary source
    HGNC:HGNC:8154
    See related
    Ensembl:ENSG00000082556 MIM:165196; AllianceGenome:HGNC:8154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
    Summary
    This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OPRK1 in Genome Data Viewer
    Location:
    8q11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (53225724..53251637, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (53602209..53628122, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54138284..54164197, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53930926-53931660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53931661-53932394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:54055436-54056635 Neighboring gene uncharacterized LOC105375836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27354 Neighboring gene EI24 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27356 Neighboring gene uncharacterized LOC124901946 Neighboring gene DNA polymerase epsilon 2, accessory subunit pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
    Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled opioid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynorphin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynorphin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynorphin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in conditioned place preference IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of luteinizing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of saliva secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to acrylamide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensory perception of temperature stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kappa-type opioid receptor
    Names
    Opiate receptor, kappa-1
    kappa opioid receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000912.5NP_000903.2  kappa-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_000903.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      AK023198, AY466378, BC099912, DA264471, U17298
      Consensus CDS
      CCDS6152.1
      UniProtKB/Swiss-Prot
      E5RHC9, P41145, Q499G4
      UniProtKB/TrEMBL
      B2R7P1
      Related
      ENSP00000265572.3, ENST00000265572.8
      Conserved Domains (1) summary
      cd15091
      Location:60341
      7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001282904.2NP_001269833.1  kappa-type opioid receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC009646, AK310407, BF061371
      Consensus CDS
      CCDS64895.1
      UniProtKB/Swiss-Prot
      P41145
      Related
      ENSP00000430923.1, ENST00000524278.5
      Conserved Domains (1) summary
      pfam00001
      Location:1241
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001318497.2NP_001305426.1  kappa-type opioid receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AK023198, AY466378, BC099912, DA264471, U17298
      Consensus CDS
      CCDS94292.1
      UniProtKB/TrEMBL
      A0A5F9ZI09, B2R7P1
      Related
      ENSP00000500765.2, ENST00000673285.2
      Conserved Domains (2) summary
      pfam00001
      Location:76330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:71271
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      53225724..53251637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      53602209..53628122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)