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    CCDC73 coiled-coil domain containing 73 [ Homo sapiens (human) ]

    Gene ID: 493860, updated on 5-May-2024

    Summary

    Official Symbol
    CCDC73provided by HGNC
    Official Full Name
    coiled-coil domain containing 73provided by HGNC
    Primary source
    HGNC:HGNC:23261
    See related
    Ensembl:ENSG00000186714 MIM:612328; AllianceGenome:HGNC:23261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NY-SAR-79
    Expression
    Ubiquitous expression in testis (RPKM 4.3), ovary (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCDC73 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32602721..32830585, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32738233..32965867, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32624267..32816208, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene WT1 antisense RNA Neighboring gene MPRA-validated peak1244 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene eukaryotic translation initiation factor 3 subunit M Neighboring gene 60S ribosomal protein L34-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:32912708-32913282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3227 Neighboring gene proline rich and Gla domain 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4568 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32968504-32968654 Neighboring gene glutamine and serine rich 1 Neighboring gene uncharacterized LOC105376615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33022947-33023448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3230 Neighboring gene DEP domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 73
    Names
    sarcoma antigen NY-SAR-79

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008391.4NP_001008392.2  coiled-coil domain-containing protein 73

      See identical proteins and their annotated locations for NP_001008392.2

      Status: VALIDATED

      Source sequence(s)
      AL035400, AL049714, AL078477, AL096793
      Consensus CDS
      CCDS41630.1
      UniProtKB/Swiss-Prot
      Q6P5Q7, Q6ZMW0, Q6ZRK6, Q86WE7
      Related
      ENSP00000335325.5, ENST00000335185.10
      Conserved Domains (2) summary
      pfam15818
      Location:271070
      CCDC73; Coiled-coil domain-containing protein 73 family
      cl12013
      Location:47220
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      32602721..32830585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427029.1XP_047282985.1  coiled-coil domain-containing protein 73 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5Q7, Q6ZMW0, Q6ZRK6, Q86WE7
    2. XM_047427030.1XP_047282986.1  coiled-coil domain-containing protein 73 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5Q7, Q6ZMW0, Q6ZRK6, Q86WE7
    3. XM_047427031.1XP_047282987.1  coiled-coil domain-containing protein 73 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      32738233..32965867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368972.1XP_054224947.1  coiled-coil domain-containing protein 73 isoform X1

      UniProtKB/Swiss-Prot
      Q6P5Q7, Q6ZMW0, Q6ZRK6, Q86WE7
    2. XM_054368973.1XP_054224948.1  coiled-coil domain-containing protein 73 isoform X2