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    ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4919, updated on 17-Jun-2024

    Summary

    Official Symbol
    ROR1provided by HGNC
    Official Full Name
    receptor tyrosine kinase like orphan receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:10256
    See related
    Ensembl:ENSG00000185483 MIM:602336; AllianceGenome:HGNC:10256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTRKR1; dJ537F10.1
    Summary
    This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
    Expression
    Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ROR1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (63774017..64181498)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63649841..64057220)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64239688..64647181)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378771 Neighboring gene phosphoglucomutase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:64140637-64141138 Neighboring gene RNA, 7SL, cytoplasmic 130, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:64179745-64180246 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:64187597-64188096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:64197420-64197975 Neighboring gene Sharpr-MPRA regulatory region 14006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 952 Neighboring gene Sharpr-MPRA regulatory region 13784 Neighboring gene Sharpr-MPRA regulatory region 321 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:64246221-64246776 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:64260455-64261114 Neighboring gene ribosomal protein L19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 953 Neighboring gene cofilin 1 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:64371900-64372424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 954 Neighboring gene Sharpr-MPRA regulatory region 8799 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene ROR1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:64620864-64621414 Neighboring gene uncharacterized LOC105378773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64661738-64662238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64662239-64662739 Neighboring gene Sharpr-MPRA regulatory region 11272 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:64728314-64729513 Neighboring gene ubiquitin conjugating enzyme E2 U

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC99659

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inner ear development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inactive tyrosine-protein kinase transmembrane receptor ROR1
    Names
    neurotrophic tyrosine kinase, receptor-related 1
    NP_001077061.1
    NP_005003.2
    XP_011539828.1
    XP_016856865.1
    XP_016856866.1
    XP_054192774.1
    XP_054192775.1
    XP_054192776.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032801.2 RefSeqGene

      Range
      4999..412480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083592.2NP_001077061.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001077061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks an in-frame portion of the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter C-terminus that lacks a tyrosine kinase catalytic domain, compared to isoform 1.
      Source sequence(s)
      AL137859, AL161742, AL445205, BC080541
      Consensus CDS
      CCDS41344.1
      UniProtKB/Swiss-Prot
      Q01973
      Related
      ENSP00000360121.1, ENST00000371080.5
      Conserved Domains (3) summary
      cd07467
      Location:166307
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:311392
      KR; Kringle domain
      smart00410
      Location:66148
      IG_like; Immunoglobulin like
    2. NM_005012.4NP_005003.2  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_005003.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK000776, AK308088, AL137859, AL161742, AL445205, M97675
      Consensus CDS
      CCDS626.1
      UniProtKB/Swiss-Prot
      Q01973, Q5VVX6, Q66K77, Q92776
      UniProtKB/TrEMBL
      A2VCQ3
      Related
      ENSP00000360120.1, ENST00000371079.6
      Conserved Domains (4) summary
      cd07467
      Location:166307
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:311393
      KR; Kringle domain
      smart00410
      Location:66148
      IG_like; Immunoglobulin like
      cd05090
      Location:467749
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      63774017..64181498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541526.2XP_011539828.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      See identical proteins and their annotated locations for XP_011539828.1

      UniProtKB/TrEMBL
      A2VCQ3
      Conserved Domains (4) summary
      cd07467
      Location:103244
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:248330
      KR; Kringle domain
      smart00409
      Location:385
      IG; Immunoglobulin
      cd05090
      Location:404686
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
    2. XM_017001377.2XP_016856866.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      UniProtKB/TrEMBL
      A2VCQ3
      Conserved Domains (4) summary
      cd07467
      Location:103244
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:248330
      KR; Kringle domain
      smart00409
      Location:385
      IG; Immunoglobulin
      cd05090
      Location:404686
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
    3. XM_017001376.2XP_016856865.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

      UniProtKB/TrEMBL
      A2VCQ3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      63649841..64057220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336800.1XP_054192775.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      UniProtKB/TrEMBL
      A2VCQ3
    2. XM_054336801.1XP_054192776.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      UniProtKB/TrEMBL
      A2VCQ3
    3. XM_054336799.1XP_054192774.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

      UniProtKB/TrEMBL
      A2VCQ3