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    NTF3 neurotrophin 3 [ Homo sapiens (human) ]

    Gene ID: 4908, updated on 27-Nov-2024

    Summary

    Official Symbol
    NTF3provided by HGNC
    Official Full Name
    neurotrophin 3provided by HGNC
    Primary source
    HGNC:HGNC:8023
    See related
    Ensembl:ENSG00000185652 MIM:162660; AllianceGenome:HGNC:8023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NT3; HDNF; NGF2; NT-3; NGF-2
    Summary
    The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 4.8), spleen (RPKM 2.1) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NTF3 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (5430332..5495299)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (5437400..5502089)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (5541274..5604465)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369617 Neighboring gene Sharpr-MPRA regulatory region 8722 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:5355081-5355848 Neighboring gene long intergenic non-protein coding RNA 2443 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:5377405-5378062 Neighboring gene 12p13 proximal LINE-mediated recombination region Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5399277-5399846 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5399847-5400415 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:5497373-5498572 Neighboring gene uncharacterized LOC105369618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5542091-5542616 Neighboring gene uncharacterized LOC124902865 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:5618629-5619828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:5626075-5626631 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:5629720-5630919 Neighboring gene OCT4 hESC enhancer GRCh37_chr12:5681388-5681889 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene anoctamin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129711

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nerve growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in induction of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neurotrophin-3
    Names
    nerve growth factor 2
    neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050629.1 RefSeqGene

      Range
      4995..68186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001102654.2NP_001096124.1  neurotrophin-3 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001096124.1

      Status: REVIEWED

      Source sequence(s)
      AC007848, BC069773, BU939830, CD672441, CN267386
      Consensus CDS
      CCDS44806.1
      UniProtKB/Swiss-Prot
      P20783
      Related
      ENSP00000397297.2, ENST00000423158.4
      Conserved Domains (1) summary
      pfam00243
      Location:157266
      NGF; Nerve growth factor family
    2. NM_002527.5NP_002518.1  neurotrophin-3 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_002518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC069773, CD672441
      Consensus CDS
      CCDS8538.1
      UniProtKB/Swiss-Prot
      B7Z1T5, P20783, Q6FH50
      Related
      ENSP00000328738.6, ENST00000331010.7
      Conserved Domains (1) summary
      pfam00243
      Location:144253
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      5430332..5495299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428901.1XP_047284857.1  neurotrophin-3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z1T5, P20783, Q6FH50
    2. XM_011520963.3XP_011519265.1  neurotrophin-3 isoform X1

      See identical proteins and their annotated locations for XP_011519265.1

      UniProtKB/Swiss-Prot
      B7Z1T5, P20783, Q6FH50
      Conserved Domains (1) summary
      pfam00243
      Location:144253
      NGF; Nerve growth factor family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      5437400..5502089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372132.1XP_054228107.1  neurotrophin-3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z1T5, P20783, Q6FH50
    2. XM_054372133.1XP_054228108.1  neurotrophin-3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z1T5, P20783, Q6FH50