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    NRDC nardilysin convertase [ Homo sapiens (human) ]

    Gene ID: 4898, updated on 2-Nov-2024

    Summary

    Official Symbol
    NRDCprovided by HGNC
    Official Full Name
    nardilysin convertaseprovided by HGNC
    Primary source
    HGNC:HGNC:7995
    See related
    Ensembl:ENSG00000078618 MIM:602651; AllianceGenome:HGNC:7995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRD1; hNRD1; hNRD2
    Summary
    This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in testis (RPKM 55.2), skin (RPKM 27.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NRDC in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (51789210..51878727, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (51669503..51759610, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52254882..52344399, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 9 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene solute carrier family 25 member 6 pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:52195252-52195772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 881 Neighboring gene Sharpr-MPRA regulatory region 3774 Neighboring gene MPRA-validated peak222 silencer Neighboring gene MPRA-validated peak223 silencer Neighboring gene microRNA 761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52342189-52342720 Neighboring gene Sharpr-MPRA regulatory region 5937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:52345137-52345690 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:52346444-52346641 Neighboring gene MPRA-validated peak224 silencer Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:52362999-52364198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1029 Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RNA, 5S ribosomal pseudogene 48 Neighboring gene ribosomal protein S26 pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, nardilysin (N-arginine dibasic convertase) (NRD1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NRD1 is decreased by RRE PubMed
    Vif vif HIV-1 Vif interacts with NRDC; interaction predicted to be relevant to proteolysis PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables epidermal growth factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nardilysin
    Names
    NRD convertase
    nardilysin (N-arginine dibasic convertase)
    NP_001095132.1
    NP_001229290.1
    NP_002516.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029171.2 RefSeqGene

      Range
      5211..94728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001101662.2NP_001095132.1  nardilysin isoform b precursor

      See identical proteins and their annotated locations for NP_001095132.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AY360265, BC008775, DA245717, X93209
      Consensus CDS
      CCDS41335.1
      UniProtKB/Swiss-Prot
      A6NI41, O15241, O15242, O43847, Q5VUL0, Q96HB2, Q9NU57
      UniProtKB/TrEMBL
      B4DRI0
      Related
      ENSP00000262679.8, ENST00000352171.12
      Conserved Domains (1) summary
      cl25708
      Location:1031089
      Peptidase_M16; Insulinase (Peptidase family M16)
    2. NM_001242361.2NP_001229290.1  nardilysin isoform c

      See identical proteins and their annotated locations for NP_001229290.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AY360265, BC008775, DB084774
      Consensus CDS
      CCDS55599.1
      UniProtKB/TrEMBL
      G3V1R5, Q6UUU9
      Related
      ENSP00000444416.1, ENST00000539524.5
      Conserved Domains (1) summary
      cl25708
      Location:1471025
      Peptidase_M16; Insulinase (Peptidase family M16)
    3. NM_002525.3NP_002516.2  nardilysin isoform a

      See identical proteins and their annotated locations for NP_002516.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AY360265, BC008775, DA245717, X93207
      Consensus CDS
      CCDS559.1
      UniProtKB/TrEMBL
      Q6UUU9
      Related
      ENSP00000346890.7, ENST00000354831.11
      Conserved Domains (4) summary
      COG1025
      Location:2791157
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:279405
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:430616
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:621902
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      51789210..51878727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      51669503..51759610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)