NPY5R neuropeptide Y receptor Y5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPY5Rprovided by HGNC
Official Full Name: neuropeptide Y receptor Y5provided by HGNC
Primary source: HGNC:HGNC:7958
See related: Ensembl:ENSG00000164129 MIM:602001; AllianceGenome:HGNC:7958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPYR5; NPY5-R; NPYY5-R
Summary: The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression: Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q32.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (163343892..163352403)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (166691703..166700212)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (164265044..164273086)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
Title: Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
Title: Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
Y1R and Y5R might be the dominant receptors that mediate the effect of NPY-induced fat accumulation in both subcutaneous and visceral adipose tissues. Y1R and Y5R in visceral adipose tissue might be targets of drug development in prevention or treatment of obesity.
Title: Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.
NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
Title: Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
Title: Genetic association analysis of 30 genes related to obesity in a European American population.
these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
Title: Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
Title: Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
Title: Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NPY5R_960 (e-PCR)
- UniSTS:277538

NPY5R_V236 (e-PCR)
- UniSTS:277538

PMC310777P8 (e-PCR)
- UniSTS:272692

PMC310777P9 (e-PCR)
- UniSTS:272693

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	TAS Traceable Author Statement more info	PubMed
enables pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide YY receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide YY receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cardiac left ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in generation of ovulation cycle rhythm	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signaling	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 5

Names: NPY-Y5 receptor; Y5 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317091.2 → NP_001304020.1 neuropeptide Y receptor type 5

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

BC034224

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916

Related

ENSP00000423917.1, ENST00000515560.1

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001317092.2 → NP_001304021.1 neuropeptide Y receptor type 5

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC042416, HY025097

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916

Related

ENSP00000589981.1, ENST00000919922.1

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_006174.4 → NP_006165.1 neuropeptide Y receptor type 5

See identical proteins and their annotated locations for NP_006165.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC042416, BI464162

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916

Related

ENSP00000339377.3, ENST00000338566.8

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

163343892..163352403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011532017.3 → XP_011530319.1 neuropeptide Y receptor type 5 isoform X2

See identical proteins and their annotated locations for XP_011530319.1

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916

Related

ENSP00000589982.1, ENST00000919923.1

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_005263038.4 → XP_005263095.1 neuropeptide Y receptor type 5 isoform X2

See identical proteins and their annotated locations for XP_005263095.1

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916

Related

ENSP00000571904.1, ENST00000901845.1

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017008256.2 → XP_016863745.1 neuropeptide Y receptor type 5 isoform X1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor
XM_011532015.3 → XP_011530317.1 neuropeptide Y receptor type 5 isoform X1

See identical proteins and their annotated locations for XP_011530317.1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor
XM_047415745.1 → XP_047271701.1 neuropeptide Y receptor type 5 isoform X1
XM_017008255.2 → XP_016863744.1 neuropeptide Y receptor type 5 isoform X1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

166691703..166700212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054350126.1 → XP_054206101.1 neuropeptide Y receptor type 5 isoform X2

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916
XM_054350125.1 → XP_054206100.1 neuropeptide Y receptor type 5 isoform X2

UniProtKB/Swiss-Prot

Q15761, Q6GTR7, Q92916
XM_054350122.1 → XP_054206097.1 neuropeptide Y receptor type 5 isoform X1
XM_054350121.1 → XP_054206096.1 neuropeptide Y receptor type 5 isoform X1
XM_054350124.1 → XP_054206099.1 neuropeptide Y receptor type 5 isoform X1
XM_054350123.1 → XP_054206098.1 neuropeptide Y receptor type 5 isoform X1