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    NPY1R neuropeptide Y receptor Y1 [ Homo sapiens (human) ]

    Gene ID: 4886, updated on 17-Jun-2024

    Summary

    Official Symbol
    NPY1Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y1provided by HGNC
    Primary source
    HGNC:HGNC:7956
    See related
    Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPYR; NPY1-R
    Summary
    This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NPY1R in Genome Data Viewer
    Location:
    4q32.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163323962..163344689, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166671793..166692717, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164245114..164253748, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75696 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:164238175-164238759 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene transketolase like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide Y receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pancreatic polypeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide YY receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuropeptide Y receptor type 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000909.6NP_000900.1  neuropeptide Y receptor type 1

      See identical proteins and their annotated locations for NP_000900.1

      Status: VALIDATED

      Source sequence(s)
      AC079238, BC036657
      Consensus CDS
      CCDS34089.1
      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Related
      ENSP00000354652.2, ENST00000296533.3
      Conserved Domains (2) summary
      pfam00001
      Location:57320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52176
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      163323962..163344689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263031.5XP_005263088.1  neuropeptide Y receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_005263088.1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Conserved Domains (2) summary
      pfam00001
      Location:57320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52176
      7tm_4; Olfactory receptor
    2. XM_011532010.4XP_011530312.1  neuropeptide Y receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011530312.1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Conserved Domains (2) summary
      pfam00001
      Location:57320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52176
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      166671793..166692717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350119.1XP_054206094.1  neuropeptide Y receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
    2. XM_054350120.1XP_054206095.1  neuropeptide Y receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929